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The Plastic Brain

Overview of attention for book
Attention for Chapter 2: CREB at the Crossroads of Activity-Dependent Regulation of Nervous System Development and Function
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Chapter title
CREB at the Crossroads of Activity-Dependent Regulation of Nervous System Development and Function
Chapter number 2
Book title
The Plastic Brain
Published in
Advances in experimental medicine and biology, January 2017
DOI 10.1007/978-3-319-62817-2_2
Pubmed ID
Book ISBNs
978-3-31-962815-8, 978-3-31-962817-2
Authors

Yesser H. Belgacem, Laura N. Borodinsky

Abstract

The central nervous system is a highly plastic network of cells that constantly adjusts its functions to environmental stimuli throughout life. Transcription-dependent mechanisms modify neuronal properties to respond to external stimuli regulating numerous developmental functions, such as cell survival and differentiation, and physiological functions such as learning, memory, and circadian rhythmicity. The discovery and cloning of the cyclic adenosine monophosphate (cAMP) responsive element binding protein (CREB) constituted a big step toward deciphering the molecular mechanisms underlying neuronal plasticity. CREB was first discovered in learning and memory studies as a crucial mediator of activity-dependent changes in target gene expression that in turn impose long-lasting modifications of the structure and function of neurons. In this chapter, we review the molecular and signaling mechanisms of neural activity-dependent recruitment of CREB and its cofactors. We discuss the crosstalk between signaling pathways that imprints diverse spatiotemporal patterns of CREB activation allowing for the integration of a wide variety of stimuli.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 42 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 21%
Student > Master 5 12%
Student > Doctoral Student 4 10%
Student > Bachelor 4 10%
Researcher 3 7%
Other 4 10%
Unknown 13 31%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 17%
Neuroscience 5 12%
Agricultural and Biological Sciences 4 10%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Nursing and Health Professions 2 5%
Other 6 14%
Unknown 16 38%