Oxygen Transport to Tissue XXXV
Springer, New York, NY
Chapter title |
Hypoxia, Lactate Accumulation, and Acidosis: Siblings or Accomplices Driving Tumor Progression and Resistance to Therapy?
|
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Chapter number | 28 |
Book title |
Oxygen Transport to Tissue XXXV
|
Published in |
Advances in experimental medicine and biology, January 2016
|
DOI | 10.1007/978-1-4614-7411-1_28 |
Pubmed ID | |
Book ISBNs |
978-1-4614-7256-8, 978-1-4614-7411-1
|
Authors |
Arnulf Mayer, Peter Vaupel |
Editors |
Sabine Van Huffel, Gunnar Naulaers, Alexander Caicedo, Duane F. Bruley, David K. Harrison |
Abstract |
This chapter briefly summarizes the most important processes by which hypoxia, lactate accumulation, and acidosis may influence malignant progression and therapeutic resistance of solid malignant tumors. While these phenomena are often elements of an integrated reaction, they may occur independently of each other under certain circumstances. The latter information may be of interest with regard to possible "targeted" therapeutic interventions. |
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South Africa | 1 | 4% |
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