Chapter title |
Modelling Blood Flow and Metabolism in the Piglet Brain During Hypoxia-Ischaemia: Simulating pH Changes.
|
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Chapter number | 44 |
Book title |
Oxygen Transport to Tissue XXXV
|
Published in |
Advances in experimental medicine and biology, January 2013
|
DOI | 10.1007/978-1-4614-7411-1_44 |
Pubmed ID | |
Book ISBNs |
978-1-4614-7256-8, 978-1-4614-7411-1
|
Authors |
Tharindi Hapuarachchi, Tracy Moroz, Alan Bainbridge, David Price, Ernest Cady, Esther Baer, Kevin Broad, Mojgan Ezzati, David Thomas, Xavier Golay, Nicola J. Robertson, Ilias Tachtsidis |
Editors |
Sabine Van Huffel, Gunnar Naulaers, Alexander Caicedo, Duane F. Bruley, David K. Harrison |
Abstract |
We describe the extension of a computational model of blood flow and metabolism in the piglet brain to investigate changes in neonatal intracellular brain pH during hypoxia-ischemia (HI). The model is able to simulate near-infrared spectroscopy (NIRS) and magnetic resonance spectroscopy (MRS) measurements obtained from HI experiments conducted in piglets. We adopt a method of using (31)P-MRS data to estimate of intracellular pH and compare measured pH and oxygenation with their modelled counterparts. We show that both NIRS and MRS measurements are predicted well in the new version of the model. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 8 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 2 | 25% |
Professor | 1 | 13% |
Other | 1 | 13% |
Student > Master | 1 | 13% |
Student > Postgraduate | 1 | 13% |
Other | 0 | 0% |
Unknown | 2 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Mathematics | 2 | 25% |
Biochemistry, Genetics and Molecular Biology | 1 | 13% |
Agricultural and Biological Sciences | 1 | 13% |
Physics and Astronomy | 1 | 13% |
Medicine and Dentistry | 1 | 13% |
Other | 0 | 0% |
Unknown | 2 | 25% |