Chapter title |
Reduction of Cytochrome c Oxidase During Vasovagal Hypoxia-Ischemia in Human Adult Brain: A Case Study
|
---|---|
Chapter number | 4 |
Book title |
Oxygen Transport to Tissue XXXV
|
Published in |
Advances in experimental medicine and biology, January 2013
|
DOI | 10.1007/978-1-4614-7411-1_4 |
Pubmed ID | |
Book ISBNs |
978-1-4614-7256-8, 978-1-4614-7411-1
|
Authors |
Ghosh, Arnab, Kolyva, Christina, Tachtsidis, Ilias, Highton, David, Elwell, Clare E., Smith, Martin, Arnab Ghosh, Christina Kolyva, Ilias Tachtsidis, David Highton, Clare E. Elwell, Martin Smith |
Editors |
Sabine Van Huffel, Gunnar Naulaers, Alexander Caicedo, Duane F. Bruley, David K. Harrison |
Abstract |
Near-infrared spectroscopy (NIRS)-derived measurement of oxidized cytochrome c oxidase concentration ([oxCCO]) has been used as an assessment of the adequacy of cerebral oxygen delivery. We report a case in which a reduction in conscious level was associated with a reduction in [oxCCO]. Hypoxaemia was induced in a 31-year-old, healthy male subject as part of an ongoing clinical study. Midway through the hypoxaemic challenge, the subject experienced an unexpected vasovagal event with bradycardia, hypotension and reduced cerebral blood flow (middle cerebral artery blood flow velocity decrease from 70 to 30 cm s(-1)) that induced a brief reduction in conscious level. An associated decrease in [oxCCO] was observed at 35 mm (-1.6 μM) but only minimal change (-0.1 μM) at 20-mm source-detector separation. A change in optical scattering was observed, but path length remained unchanged. This unexpected physiological event provides an unusual example of a severe reduction in cerebral oxygen delivery and is the first report correlating change in clinical status with changes in [oxCCO]. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 9% |
Unknown | 10 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 3 | 27% |
Researcher | 2 | 18% |
Professor | 1 | 9% |
Student > Master | 1 | 9% |
Other | 1 | 9% |
Other | 0 | 0% |
Unknown | 3 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Engineering | 3 | 27% |
Neuroscience | 2 | 18% |
Social Sciences | 1 | 9% |
Agricultural and Biological Sciences | 1 | 9% |
Medicine and Dentistry | 1 | 9% |
Other | 0 | 0% |
Unknown | 3 | 27% |