| Chapter title |
Cyclic Dinucleotides in the Scope of the Mammalian Immune System
|
|---|---|
| Chapter number | 5002 |
| Book title |
Non-canonical Cyclic Nucleotides
|
| Published in |
Handbook of experimental pharmacology, January 2016
|
| DOI | 10.1007/164_2016_5002 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-952671-3, 978-3-31-952673-7
|
| Authors |
Arun K. Mankan, Martina Müller, Gregor Witte, Veit Hornung |
| Abstract |
First discovered in prokaryotes and more recently in eukaryotes, cyclic dinucleotides (CDNs) constitute a unique branch of second messenger signaling systems. Within prokaryotes CDNs regulate a wide array of different biological processes, whereas in the vertebrate system CDN signaling is largely dedicated to activation of the innate immune system. In this book chapter we summarize the occurrence and signaling pathways of these small-molecule second messengers, most importantly in the scope of the mammalian immune system. In this regard, our main focus is the role of the cGAS-STING axis in the context of microbial infection and sterile inflammation and its implications for therapeutic applications. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 10% |
| Unknown | 9 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 40% |
| Student > Master | 2 | 20% |
| Lecturer | 1 | 10% |
| Professor | 1 | 10% |
| Unknown | 2 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 4 | 40% |
| Immunology and Microbiology | 2 | 20% |
| Medicine and Dentistry | 2 | 20% |
| Unknown | 2 | 20% |