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Statistical Human Genetics

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Cover of 'Statistical Human Genetics'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Statistical Genetic Terminology
  3. Altmetric Badge
    Chapter 2 Identification of Genotype Errors
  4. Altmetric Badge
    Chapter 3 Detecting Pedigree Relationship Errors
  5. Altmetric Badge
    Chapter 4 Identifying Cryptic Relationships
  6. Altmetric Badge
    Chapter 5 Estimating Allele Frequencies
  7. Altmetric Badge
    Chapter 6 Testing Departure from Hardy-Weinberg Proportions
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    Chapter 7 Estimating Disequilibrium Coefficients
  9. Altmetric Badge
    Chapter 8 Detecting Familial Aggregation
  10. Altmetric Badge
    Chapter 9 Estimating Heritability from Twin Studies
  11. Altmetric Badge
    Chapter 10 Estimating Heritability from Nuclear Family and Pedigree Data
  12. Altmetric Badge
    Chapter 11 Correcting for Ascertainment
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    Chapter 12 Segregation Analysis Using the Unified Model
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    Chapter 13 Design Considerations for Genetic Linkage and Association Studies
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    Chapter 14 Model-Based Linkage Analysis of a Quantitative Trait
  16. Altmetric Badge
    Chapter 15 Model-Based Linkage Analysis of a Binary Trait
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    Chapter 16 Model-Free Linkage Analysis of a Quantitative Trait
  18. Altmetric Badge
    Chapter 17 Model-Free Linkage Analysis of a Binary Trait
  19. Altmetric Badge
    Chapter 18 Single Marker Association Analysis for Unrelated Samples
  20. Altmetric Badge
    Chapter 19 Single Marker Family-Based Association Analysis Conditional on Parental Information
  21. Altmetric Badge
    Chapter 20 Single Marker Family-Based Association Analysis Not Conditional on Parental Information
  22. Altmetric Badge
    Chapter 21 Calibrating Population Stratification in Association Analysis
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    Chapter 22 Cross-Phenotype Association Analysis Using Summary Statistics from GWAS
  24. Altmetric Badge
    Chapter 23 Haplotype Inference
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    Chapter 24 Multi-SNP Haplotype Analysis Methods for Association Analysis
  26. Altmetric Badge
    Chapter 25 The Analysis of Ethnic Mixtures
  27. Altmetric Badge
    Chapter 26 Detecting Multiethnic Rare Variants
  28. Altmetric Badge
    Chapter 27 Identifying Gene Interaction Networks
  29. Altmetric Badge
    Chapter 28 Structural Equation Modeling
  30. Altmetric Badge
    Chapter 29 Mendelian Randomization
  31. Altmetric Badge
    Chapter 30 Preprocessing and Quality Control for Whole-Genome Sequences from the Illumina HiSeq X Platform
  32. Altmetric Badge
    Chapter 31 Processing and Analyzing Human Microbiome Data
Attention for Chapter 3: Detecting Pedigree Relationship Errors
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Chapter title
Detecting Pedigree Relationship Errors
Chapter number 3
Book title
Statistical Human Genetics
Published in
Methods in molecular biology, January 2017
DOI 10.1007/978-1-4939-7274-6_3
Pubmed ID
Book ISBNs
978-1-4939-7273-9, 978-1-4939-7274-6
Authors

Lei Sun

Abstract

Pedigree relationship errors often occur in family data collected for genetic studies, and unidentified errors can lead to either increased false positives or decreased power in both linkage and association analyses. Here, we review several allele sharing as well as likelihood-based statistics that were proposed to efficiently extract genealogical information from available genome-wide marker data, and the software package PREST that implements these methods. We provide the detailed analytical steps involved using two application examples, and we discuss various practical issues, including result interpretation.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 5 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 1 20%
Student > Bachelor 1 20%
Student > Doctoral Student 1 20%
Unknown 2 40%
Readers by discipline Count As %
Medicine and Dentistry 2 40%
Agricultural and Biological Sciences 1 20%
Unknown 2 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 October 2017.
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#20,449,496
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Outputs from Methods in molecular biology
#9,941
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#356,165
of 421,224 outputs
Outputs of similar age from Methods in molecular biology
#842
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