Chapter title |
Cerebrovascular Disease: Consequences of Obesity-Induced Endothelial Dysfunction
|
---|---|
Chapter number | 7 |
Book title |
Obesity and Brain Function
|
Published in |
Advances in neurobiology, January 2017
|
DOI | 10.1007/978-3-319-63260-5_7 |
Pubmed ID | |
Book ISBNs |
978-3-31-963259-9, 978-3-31-963260-5
|
Authors |
Liliana Letra, Cristina Sena, Letra, Liliana, Sena, Cristina |
Abstract |
Despite the well-known global impact of overweight and obesity in the incidence of cerebrovascular disease, many aspects of this association are still inconsistently defined. In this chapter we aim to present a critical review on the links between obesity and both ischemic and hemorrhagic stroke and discuss its influence on functional outcomes, survival, and current treatments to acute and chronic stroke. The role of cerebrovascular endothelial function and respective modulation is also described as well as its laboratory and clinical assessment. In this context, the major contributing mechanisms underlying obesity-induced cerebral endothelial function (adipokine secretion, insulin resistance, inflammation, and hypertension) are discussed. A special emphasis is given to the participation of adipokines in the pathophysiology of stroke, namely adiponectin, leptin, resistin, apelin, and visfatin. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 29 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 6 | 21% |
Student > Doctoral Student | 3 | 10% |
Student > Master | 3 | 10% |
Professor > Associate Professor | 2 | 7% |
Other | 1 | 3% |
Other | 4 | 14% |
Unknown | 10 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 34% |
Neuroscience | 2 | 7% |
Agricultural and Biological Sciences | 2 | 7% |
Unspecified | 1 | 3% |
Psychology | 1 | 3% |
Other | 1 | 3% |
Unknown | 12 | 41% |