Chapter title |
The Influence of Adipose Tissue on Brain Development, Cognition, and Risk of Neurodegenerative Disorders
|
---|---|
Chapter number | 6 |
Book title |
Obesity and Brain Function
|
Published in |
Advances in neurobiology, January 2017
|
DOI | 10.1007/978-3-319-63260-5_6 |
Pubmed ID | |
Book ISBNs |
978-3-31-963259-9, 978-3-31-963260-5
|
Authors |
Liliana Letra, Isabel Santana, Letra, Liliana, Santana, Isabel |
Abstract |
The brain is a highly metabolic organ and thus especially vulnerable to changes in peripheral metabolism, including those induced by obesity-associated adipose tissue dysfunction. In this context, it is likely that the development and maturation of neurocognitive circuits may also be affected and modulated by metabolic environmental factors, beginning in utero. It is currently recognized that maternal obesity, either pre-gestational or gestational, negatively influences fetal brain development and elevates the risk of cognitive impairment and neuropsychiatric disorders in the offspring. During infancy and adolescence, obesity remains a limiting factor for healthy neurodevelopment, especially affecting executive functions but also attention, visuospatial ability, and motor skills. In middle age, obesity seems to induce an accelerated brain aging and thus may increase the risk of age-related neurodegenerative diseases such as Alzheimer's disease. In this chapter we review and discuss experimental and clinical evidence focusing on the influence of adipose tissue dysfunction on neurodevelopment and cognition across lifespan, as well as some possible mechanistic links, namely the role of the most well studied adipokines. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 33% |
United Kingdom | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
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Unknown | 58 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 10 | 17% |
Researcher | 8 | 14% |
Student > Doctoral Student | 4 | 7% |
Student > Bachelor | 4 | 7% |
Professor > Associate Professor | 2 | 3% |
Other | 5 | 9% |
Unknown | 25 | 43% |
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Psychology | 6 | 10% |
Medicine and Dentistry | 6 | 10% |
Biochemistry, Genetics and Molecular Biology | 4 | 7% |
Neuroscience | 4 | 7% |
Nursing and Health Professions | 3 | 5% |
Other | 8 | 14% |
Unknown | 27 | 47% |