Chapter title |
Function and Dysfunction of Adipose Tissue
|
---|---|
Chapter number | 1 |
Book title |
Obesity and Brain Function
|
Published in |
Advances in neurobiology, January 2017
|
DOI | 10.1007/978-3-319-63260-5_1 |
Pubmed ID | |
Book ISBNs |
978-3-31-963259-9, 978-3-31-963260-5
|
Authors |
Paulo Matafome, Raquel Seiça |
Abstract |
Adipose tissue is an endocrine organ which is responsible for postprandial uptake of glucose and fatty acids, consequently producing a broad range of adipokines controlling several physiological functions like appetite, insulin sensitivity and secretion, immunity, coagulation, and vascular tone, among others. Many aspects of adipose tissue pathophysiology in metabolic diseases have been described in the last years. Recent data suggest two main factors for adipose tissue dysfunction: accumulation of nonesterified fatty acids and their secondary products and hypoxia. Both of these factors are thought to be on the basis of low-grade inflammatory activation, further increasing metabolic dysregulation in adipose tissue. In turn, inflammation is involved in the inhibition of substrate uptake, alteration of the secretory profile, stimulation of angiogenesis, and recruitment of further inflammatory cells, which creates an inflammatory feedback in the tissue and is responsible for long-term establishment of insulin resistance. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 63 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 8 | 13% |
Student > Bachelor | 8 | 13% |
Student > Ph. D. Student | 7 | 11% |
Researcher | 5 | 8% |
Student > Doctoral Student | 5 | 8% |
Other | 12 | 19% |
Unknown | 18 | 29% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 10 | 16% |
Medicine and Dentistry | 9 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 8% |
Immunology and Microbiology | 4 | 6% |
Nursing and Health Professions | 3 | 5% |
Other | 8 | 13% |
Unknown | 24 | 38% |