Chapter title |
Multiple Sclerosis: Implications of Obesity in Neuroinflammation
|
---|---|
Chapter number | 8 |
Book title |
Obesity and Brain Function
|
Published in |
Advances in neurobiology, January 2017
|
DOI | 10.1007/978-3-319-63260-5_8 |
Pubmed ID | |
Book ISBNs |
978-3-31-963259-9, 978-3-31-963260-5
|
Authors |
Ana Margarida Novo, Sónia Batista |
Abstract |
Since the discovery of the remarkable properties of adipose tissue as a metabolically active organ, several evidences on the possible link between obesity and the pathogenesis of multiple sclerosis (MS) have been gathered. Obesity in early life, mainly during adolescence, has been proposed as a relevant risk factor for late MS development. Moreover, once MS is initiated, obesity can contribute to increase disease severity by negatively influencing disease progress. Despite the fact that clinical data are not yet conclusive, many biochemical links have been recently disclosed. The "low-grade inflammation" that characterizes obesity can lead to neuroinflammation through different mechanisms, including choroid plexus and blood-brain barrier disruption. Furthermore, it is well known that resident immune cells of central nervous system and peripheral immune cells are involved in the pathogenesis of MS, and adipokines and neuropeptides such as neuropeptide Y may mediate the cross talk between them. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
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Unknown | 41 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Doctoral Student | 5 | 12% |
Student > Ph. D. Student | 5 | 12% |
Student > Master | 4 | 10% |
Student > Bachelor | 3 | 7% |
Other | 2 | 5% |
Other | 4 | 10% |
Unknown | 18 | 44% |
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Biochemistry, Genetics and Molecular Biology | 1 | 2% |
Agricultural and Biological Sciences | 1 | 2% |
Sports and Recreations | 1 | 2% |
Other | 3 | 7% |
Unknown | 20 | 49% |