| Chapter title |
History of Electrophysiology and the Patch Clamp
|
|---|---|
| Chapter number | 1 |
| Book title |
Patch-Clamp Methods and Protocols
|
| Published in |
Methods in molecular biology, June 2014
|
| DOI | 10.1007/978-1-4939-1096-0_1 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-1095-3, 978-1-4939-1096-0
|
| Authors |
Verkhratsky A, Parpura V, Alexei Verkhratsky, Vladimir Parpura, Verkhratsky, Alexei, Parpura, Vladimir |
| Abstract |
We provide a historic outlook on the development of the concept of bioelectricity, with emphasis on the neuromuscular junction as a model that revolutionized our thinking of the nerve, nervous, and muscle tissue excitability. We abridge some crucial experiments in defining the electrical excitability of biological cells. We also provide an insight into developments of tools and methods, which gradually yielded a contemporary "palette" of electrophysiology approaches, including the patch clamp. Pioneering steps in this journey, ranging from Galvani's experiments using the Leyden jar to those of Neher and Sakmann using a gigaseal patch-clamp approach, are pictorially illustrated. This chapter is meant to be a perspective to the following sections in this volume dedicated to patch-clamp methods and protocols. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Spain | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Portugal | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 217 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 45 | 20% |
| Researcher | 40 | 18% |
| Student > Master | 26 | 12% |
| Student > Bachelor | 24 | 11% |
| Student > Doctoral Student | 17 | 8% |
| Other | 29 | 13% |
| Unknown | 39 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 54 | 25% |
| Agricultural and Biological Sciences | 47 | 21% |
| Biochemistry, Genetics and Molecular Biology | 22 | 10% |
| Engineering | 12 | 5% |
| Physics and Astronomy | 10 | 5% |
| Other | 28 | 13% |
| Unknown | 47 | 21% |