Chapter title |
Mouse and Rat Models of Induction of Hepatic Fibrosis and Assessment of Portal Hypertension
|
---|---|
Chapter number | 7 |
Book title |
Fibrosis
|
Published in |
Methods in molecular biology, January 2017
|
DOI | 10.1007/978-1-4939-7113-8_7 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7112-1, 978-1-4939-7113-8
|
Authors |
Sabine Klein, Robert Schierwagen, Frank Erhard Uschner, Jonel Trebicka |
Abstract |
Portal hypertension either develops due to progressive liver fibrosis or is the consequence of vascular liver diseases such as portal vein thrombosis or non-cirrhotic portal hypertension. This chapter focuses on different rodent models of liver fibrosis with portal hypertension and also in few non-cirrhotic portal hypertension models. Importantly, after the development of portal hypertension, the proper assessment of drug effects in the portal and systemic circulation should be discussed. The last part of the chapter is dedicated in these techniques to assess the in vivo hemodynamics and the ex vivo techniques of the isolated liver perfusion and vascular contractility. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 5 | 36% |
Student > Ph. D. Student | 2 | 14% |
Professor | 2 | 14% |
Other | 1 | 7% |
Student > Master | 1 | 7% |
Other | 1 | 7% |
Unknown | 2 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 36% |
Biochemistry, Genetics and Molecular Biology | 3 | 21% |
Agricultural and Biological Sciences | 2 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 7% |
Unknown | 3 | 21% |