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Mendeley readers
| Chapter title |
The Role of Centromere Defects in Cancer
|
|---|---|
| Chapter number | 22 |
| Book title |
Centromeres and Kinetochores
|
| Published in |
Progress in molecular and subcellular biology, August 2017
|
| DOI | 10.1007/978-3-319-58592-5_22 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-958591-8, 978-3-31-958592-5
|
| Authors |
Thian Thian Beh, Paul Kalitsis |
| Abstract |
The accurate segregation of chromosomes to daughter cells is essential for healthy development to occur. Imbalances in chromosome number have long been associated with cancers amongst other medical disorders. Little is known whether abnormal chromosome numbers are an early contributor to the cancer progression pathway. Centromere DNA and protein defects are known to impact on the fidelity of chromosome segregation in cell and model systems. In this chapter we discuss recent developments in understanding the contribution of centromere abnormalities at the protein and DNA level and their role in cancer in human and mouse systems. |
Mendeley readers
The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 8 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 2 | 25% |
| Student > Bachelor | 1 | 13% |
| Student > Doctoral Student | 1 | 13% |
| Professor | 1 | 13% |
| Student > Postgraduate | 1 | 13% |
| Other | 0 | 0% |
| Unknown | 2 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 4 | 50% |
| Medicine and Dentistry | 2 | 25% |
| Unknown | 2 | 25% |