Chapter title |
Orchestrating the Specific Assembly of Centromeric Nucleosomes
|
---|---|
Chapter number | 7 |
Book title |
Progress in Molecular and Subcellular Biology
|
Published in |
Progress in molecular and subcellular biology, August 2017
|
DOI | 10.1007/978-3-319-58592-5_7 |
Pubmed ID | |
Book ISBNs |
978-3-31-958591-8, 978-3-31-958592-5
|
Authors |
Zasadzińska, Ewelina, Foltz, Daniel R., Ewelina Zasadzińska, Daniel R. Foltz |
Abstract |
Centromeres are chromosomal loci that are defined epigenetically in most eukaryotes by incorporation of a centromere-specific nucleosome in which the canonical histone H3 variant is replaced by Centromere Protein A (CENP-A). Therefore, the assembly and propagation of centromeric nucleosomes are critical for maintaining centromere identify and ensuring genomic stability. Centromeres direct chromosome segregation (during mitosis and meiosis) by recruiting the constitutive centromere-associated network of proteins throughout the cell cycle that in turn recruits the kinetochore during mitosis. Assembly of centromere-specific nucleosomes in humans requires the dedicated CENP-A chaperone HJURP, and the Mis18 complex to couple the deposition of new CENP-A to the site of the pre-existing centromere, which is essential for maintaining centromere identity. Human CENP-A deposition occurs specifically in early G1, into pre-existing chromatin, and several additional chromatin-associated complexes regulate CENP-A nucleosome deposition and stability. Here we review the current knowledge on how new CENP-A nucleosomes are assembled selectively at the existing centromere in different species and how this process is controlled to ensure stable epigenetic inheritance of the centromere. |
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