Chapter title |
Red Blood Cells: A Source of Extracellular Vesicles
|
---|---|
Chapter number | 2 |
Book title |
Extracellular Vesicles
|
Published in |
Methods in molecular biology, January 2017
|
DOI | 10.1007/978-1-4939-7253-1_2 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7251-7, 978-1-4939-7253-1
|
Authors |
Winston Patrick Kuo, John C. Tigges, Vasilis Toxavidis, Ionita Ghiran, Kuo, Winston Patrick, Tigges, John C., Toxavidis, Vasilis, Ghiran, Ionita |
Abstract |
During their lifetime, like all other cell types, red blood cells (RBCs) release both exosomes and plasma membrane derived EVs (ectosomes). RBC exosomes are formed only during the development of RBCs in bone marrow, and are released following the fusion of microvesicular bodies (MVB) with the plasma membrane. On the other hand, RBC EVs are generated during normal aging of RBCs in circulation by budding of the plasma membrane due to complement -mediated calcium influx, followed by vesicle shedding. This makes red blood cells and stored red cells a reliable source of EVs for basic and clinical research. |
Mendeley readers
Geographical breakdown
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Unknown | 64 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 10 | 16% |
Researcher | 7 | 11% |
Student > Postgraduate | 6 | 9% |
Student > Master | 5 | 8% |
Student > Doctoral Student | 4 | 6% |
Other | 8 | 13% |
Unknown | 24 | 38% |
Readers by discipline | Count | As % |
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Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Other | 4 | 6% |
Unknown | 27 | 42% |