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Avian and Reptilian Developmental Biology

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Cover of 'Avian and Reptilian Developmental Biology'

Table of Contents

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    Book Overview
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    Chapter 1 Some Thoughts on Experimental Design
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    Chapter 2 Comparative Genomics as a Foundation for Evo-Devo Studies in Birds
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    Chapter 3 A Step-by-Step Guide to Assemble a Reptilian Genome
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    Chapter 4 Genomic and Transcriptomic Analyses of Avian Sex Chromosomes and Sex-Linked Genes
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    Chapter 5 Systems Biology Analyses in Chicken: Workflow for Transcriptome and ChIP-Seq Analyses Using the Chicken Skin Paradigm
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    Chapter 6 Application of a CAGE Method to an Avian Development Study
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    Chapter 7 CRISPR/Cas9 in the Chicken Embryo
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    Chapter 8 Fluorescent Quail: A Transgenic Model System for the Dynamic Study of Avian Development
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    Chapter 9 Lentiviral-Mediated Transgenesis in Songbirds
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    Chapter 10 In Ovo Electroporation Methods in Chick Embryos
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    Chapter 11 Genetic Manipulation of the Avian Urogenital System Using In Ovo Electroporation
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    Chapter 12 Enhancer Analyses Using Chicken Embryo Electroporation
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    Chapter 13 Transgene Introduction into the Chick Limb Bud by Electroporation
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    Chapter 14 Chicken Induced Pluripotent Stem Cells: Establishment and Characterization
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    Chapter 15 Isolation and Characterization of Chicken Primordial Germ Cells and Their Application in Transgenesis
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    Chapter 16 Handling of Gametes for In Vitro Insemination in Birds
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    Chapter 17 In Vitro and Ex Ovo Culture of Reptilian and Avian Neural Progenitor Cells
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    Chapter 18 Lifting the Veil on Reptile Embryology: The Veiled Chameleon (Chamaeleo calyptratus) as a Model System to Study Reptilian Development
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    Chapter 19 Model Clades Versus Model Species: Anolis Lizards as an Integrative Model of Anatomical Evolution
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    Chapter 20 The Feather Model for Chemo- and Radiation Therapy-Induced Tissue Damage
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    Chapter 21 An Early Chick Embryo Culture Device for Extended Continuous Observation
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    Chapter 22 A Sensitive and Versatile In Situ Hybridization Protocol for Gene Expression Analysis in Developing Amniote Brains
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    Chapter 23 Somitogenesis and Axial Development in Reptiles
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    Chapter 24 MicroCT Imaging on Living Alligator Teeth Reveals Natural Tooth Cycling
Attention for Chapter 20: The Feather Model for Chemo- and Radiation Therapy-Induced Tissue Damage
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Chapter title
The Feather Model for Chemo- and Radiation Therapy-Induced Tissue Damage
Chapter number 20
Book title
Avian and Reptilian Developmental Biology
Published in
Methods in molecular biology, January 2017
DOI 10.1007/978-1-4939-7216-6_20
Pubmed ID
Book ISBNs
978-1-4939-7215-9, 978-1-4939-7216-6
Authors

Zhicao Yue, Benhua Xu

Abstract

Chemo- and radiation therapy are the main modalities for cancer treatment. A major limiting factor is their toxicity to normal tissue, thus reducing the dose and duration of the therapy. The hair follicle, gastrointestinal tract, and hematopoietic system are among the target organs that often show side effects in cancer therapy . Although these organs are highly mitotic in common, the molecular mechanism of the damage remains unclear. The feather follicle is a fast-growing mini-organ, which allows observation and manipulation on each follicle individually. As a model system, the feather follicle is advantageous because of the following reasons: (1) its complex structure is regulated by a set of evolutionarily conserved molecular pathways, thus facilitating the effort to dissect the specific signaling events involved; (2) its morphology allows the continuity of normal-perturbed-normal structure in a single feather, thus "recording" the damaging effect of chemo- and radiation therapy; (3) further histological and molecular analysis of the damage response can be performed on each plucked feather; thus, it is not necessary to sacrifice the experimental animal. Here, we describe methods of applying the feather model to study the molecular mechanism of chemo- and radiation therapy-induced tissue damage.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 1 Mendeley reader of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 1 100%

Demographic breakdown

Readers by professional status Count As %
Professor 1 100%
Readers by discipline Count As %
Medicine and Dentistry 1 100%