Chapter title |
Anti-neutrophil cytoplasmic antibodies (ANCA) in autoimmune liver disease.
|
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Chapter number | 99 |
Book title |
ANCA-Associated Vasculitides
|
Published in |
Advances in experimental medicine and biology, January 1993
|
DOI | 10.1007/978-1-4757-9182-2_99 |
Pubmed ID | |
Book ISBNs |
978-1-4757-9184-6, 978-1-4757-9182-2
|
Authors |
Mulder, A H, Horst, G, Haagsma, E B, Kleibeuker, J H, Kallenberg, C G, A. H. Leontine Mulder, Gerda Horst, Els B. Haagsma, Jan H. Kleibeuker, Cees G. M. Kallenberg, Mulder, A. H. Leontine, Horst, Gerda, Haagsma, Els B., Kleibeuker, Jan H., Kallenberg, Cees G. M. |
Abstract |
ANCA were detected in 67% of sera from patients with primary sclerosing cholangitis (n = 15), in 83% of sera from patients with autoimmune chronic active hepatitis (n = 18) and in 35% of sera from patients with primary biliary cirrhosis (n = 20). ANCA were not detected in non-autoimmune chronic liver diseases. Characterization studies of the antigens involved showed that ANCA in autoimmune liver disease are not directed against myeloperoxidase (mpo), proteinase 3 (pr3) or elastase (hle), but the ANCA in autoimmune liver disease show reactivity with lactoferrin, a 67/66 kD protein combination or a 63/54 kD protein combination on Western Blots. |
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Unknown | 1 | 100% |
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