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Mitochondrial DNA

Overview of attention for book
Cover of 'Mitochondrial DNA'

Table of Contents

  1. Altmetric Badge
    Book Overview
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    Chapter 1 Comprehensive Mitochondrial Genome Analysis by Massively Parallel Sequencing.
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    Chapter 2 Mitochondrial DNA
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    Chapter 3 Quantification of DNA Damage by Real-Time qPCR
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    Chapter 4 Quantitation of Mitochondrial DNA Deletions Via Restriction Digestion/Long-Range Single-Molecule PCR
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    Chapter 5 A Single-Cell Resolution Imaging Protocol of Mitochondrial DNA Dynamics in Physiopathology, mTRIP, Which Also Evaluates Sublethal Cytotoxicity.
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    Chapter 6 Scalable Isolation of Mammalian Mitochondria for Nucleic Acid and Nucleoid Analysis
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    Chapter 7 Tracking Mitochondrial DNA In Situ
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    Chapter 8 Analysis of Replicating Mitochondrial DNA by In Organello Labeling and Two-Dimensional Agarose Gel Electrophoresis
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    Chapter 9 Translation and Assembly of Radiolabeled Mitochondrial DNA-Encoded Protein Subunits from Cultured Cells and Isolated Mitochondria
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    Chapter 10 Analysis of Mitochondrial DNA Copy Number and Its Regulation Through DNA Methylation of POLGA
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    Chapter 11 Engineered mtZFNs for Manipulation of Human Mitochondrial DNA Heteroplasmy
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    Chapter 12 Mitochondrial DNA
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    Chapter 13 Import of Fluorescent RNA into Mitochondria of Living Cells
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    Chapter 14 Purification and Comparative Assay of the Human Mitochondrial Replicative DNA Helicase
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    Chapter 15 Expression and Purification of Mitochondrial RNA Polymerase and Transcription Factor A from Drosophila melanogaster.
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    Chapter 16 Mitochondrial DNA
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    Chapter 17 Biolayer Interferometry: A Novel Method to Elucidate Protein–Protein and Protein–DNA Interactions in the Mitochondrial DNA Replisome
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    Chapter 18 ERRATUM TO: Quantitation of Mitochondrial DNA Deletions Via Restriction Digestion/Long-Range Single-Molecule PCR
Attention for Chapter 2: Mitochondrial DNA
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Chapter title
Mitochondrial DNA
Chapter number 2
Book title
Mitochondrial DNA
Published in
Methods in molecular biology, January 2016
DOI 10.1007/978-1-4939-3040-1_2
Pubmed ID
26530671
Book ISBNs
978-1-4939-3039-5, 978-1-4939-3040-1
Authors

Copeland, William C, Kasiviswanathan, Rajesh, Longley, Matthew J, William C. Copeland, Rajesh Kasiviswanathan, Matthew J. Longley

Abstract

Mitochondrial DNA is replicated by the nuclear-encoded DNA polymerase γ (pol γ) which is composed of a single 140 kDa catalytic subunit and a dimeric 55 kDa accessory subunit. Mitochondrial DNA is vulnerable to various forms of damage, including several types of oxidative lesions, UV-induced photoproducts, chemical adducts from environmental sources, as well as alkylation and inter-strand cross-links from chemotherapy agents. Although many of these lesions block DNA replication, pol γ can bypass some lesions by nucleotide incorporation opposite a template lesion and further extension of the DNA primer past the lesion. This process of translesion synthesis (TLS) by pol γ can occur in either an error-free or an error-prone manner. Assessment of TLS requires extensive analysis of oligonucleotide substrates and replication products by denaturing polyacrylamide sequencing gels. This chapter presents protocols for the analysis of translesion DNA synthesis.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 9%
Unknown 10 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 36%
Student > Bachelor 3 27%
Unspecified 1 9%
Researcher 1 9%
Unknown 2 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 36%
Agricultural and Biological Sciences 2 18%
Unspecified 1 9%
Chemical Engineering 1 9%
Unknown 3 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 September 2016.
All research outputs
#18,823,812
of 23,327,904 outputs
Outputs from Methods in molecular biology
#8,101
of 13,337 outputs
Outputs of similar age
#287,272
of 396,143 outputs
Outputs of similar age from Methods in molecular biology
#855
of 1,474 outputs
Altmetric has tracked 23,327,904 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,337 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 396,143 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1,474 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.

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