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Human T-Lymphotropic Viruses

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Cover of 'Human T-Lymphotropic Viruses'

Table of Contents

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    Book Overview
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    Chapter 1 Serological and Molecular Methods to Study Epidemiological Aspects of Human T-Cell Lymphotropic Virus Type 1 Infection
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    Chapter 2 Molecular Epidemiology Database for Sequence Management and Data Mining
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    Chapter 3 Reporter Systems to Study HTLV-1 Transmission
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    Chapter 4 Quantitative Analysis of Human T-Lymphotropic Virus Type 1 (HTLV-1) Infection Using Co-Culture with Jurkat LTR-Luciferase or Jurkat LTR-GFP Reporter Cells
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    Chapter 5 Isolation of Exosomes from HTLV-Infected Cells
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    Chapter 6 A Luciferase Functional Quantitative Assay for Measuring NF-ĸB Promoter Transactivation Mediated by HTLV-1 and HTLV-2 Tax Proteins
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    Chapter 7 Generation of a Tet-On Expression System to Study Transactivation Ability of Tax-2
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    Chapter 8 EGF Uptake and Degradation Assay to Determine the Effect of HTLV Regulatory Proteins on the ESCRT-Dependent MVB Pathway
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    Chapter 9 Methods for Identifying and Examining HTLV-1 HBZ Post-translational Modifications
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    Chapter 10 High-Throughput Mapping and Clonal Quantification of Retroviral Integration Sites
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    Chapter 11 STR Profiling of HTLV-1-Infected Cell Lines
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    Chapter 12 Expression of HTLV-1 Genes in T-Cells Using RNA Electroporation
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    Chapter 13 Quantification of Cell Turnover in the Bovine Leukemia Virus Model
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    Chapter 14 Analysis of NK Cell Function and Receptor Expression During HTLV-1 and HTLV-2 Infection
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    Chapter 15 Overview of Targeted Therapies for Adult T-Cell Leukemia/Lymphoma
Attention for Chapter 9: Methods for Identifying and Examining HTLV-1 HBZ Post-translational Modifications
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Chapter title
Methods for Identifying and Examining HTLV-1 HBZ Post-translational Modifications
Chapter number 9
Book title
Human T-Lymphotropic Viruses
Published in
Methods in molecular biology, January 2017
DOI 10.1007/978-1-4939-6872-5_9
Pubmed ID
Book ISBNs
978-1-4939-6870-1, 978-1-4939-6872-5
Authors

Jacob Al-Saleem, Mamuka Kvaratskhelia, Patrick L. Green, Al-Saleem, Jacob, Kvaratskhelia, Mamuka, Green, Patrick L.

Abstract

Post-translational modifications (PTMs) are chemical alterations to individual amino acids that alter a protein's conformation, stability, and/or function. Several pathogenic viruses have been shown to encode proteins with PTMs, including human T-cell leukemia virus type 1 (HTLV-1) Tax and Rex regulatory proteins. HTLV-1 basic leucine zipper protein (HBZ) was hypothesized to feature PTMs due to its functional activities and interactions with cellular transcription factors and acetyltransferases. Here, we describe the approach used to identify, via mass spectrometry, the PTMs of HBZ. In addition, we describe methods to determine the functional relevance of the identified PTMs.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 4 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 4 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 75%
Researcher 1 25%
Readers by discipline Count As %
Medicine and Dentistry 2 50%
Immunology and Microbiology 1 25%
Unknown 1 25%