| Chapter title |
Unbalanced Growth, Senescence and Aging
|
|---|---|
| Chapter number | 8 |
| Book title |
Cell Division Machinery and Disease
|
| Published in |
Advances in experimental medicine and biology, June 2017
|
| DOI | 10.1007/978-3-319-57127-0_8 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-957125-6, 978-3-31-957127-0
|
| Authors |
Michael Polymenis, Brian K. Kennedy, Polymenis, Michael, Kennedy, Brian K. |
| Editors |
Monica Gotta, Patrick Meraldi |
| Abstract |
Usually, cells balance their growth with their division. Coordinating growth inputs with cell division ensures the proper timing of division when sufficient cell material is available and affects the overall rate of cell proliferation. At a very fundamental level, cellular replicative lifespan-defined as the number of times a cell can divide, is a manifestation of cell cycle control. Hence, control of mitotic cell divisions, especially when the commitment is made to a new round of cell division, is intimately linked to replicative aging of cells. In this chapter, we review our current understanding, and its shortcomings, of how unbalanced growth and division, can dramatically influence the proliferative potential of cells, often leading to cellular and organismal aging phenotypes. The interplay between growth and division also underpins cellular senescence (i.e., inability to divide) and quiescence, when cells exit the cell cycle but still retain their ability to divide. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 24 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 17% |
| Student > Master | 3 | 13% |
| Researcher | 3 | 13% |
| Student > Bachelor | 2 | 8% |
| Professor | 1 | 4% |
| Other | 2 | 8% |
| Unknown | 9 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 8 | 33% |
| Arts and Humanities | 1 | 4% |
| Nursing and Health Professions | 1 | 4% |
| Agricultural and Biological Sciences | 1 | 4% |
| Immunology and Microbiology | 1 | 4% |
| Other | 4 | 17% |
| Unknown | 8 | 33% |