| Chapter title |
Dividing with Extra Centrosomes: A Double Edged Sword for Cancer Cells
|
|---|---|
| Chapter number | 3 |
| Book title |
Cell Division Machinery and Disease
|
| Published in |
Advances in experimental medicine and biology, June 2017
|
| DOI | 10.1007/978-3-319-57127-0_3 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-957125-6, 978-3-31-957127-0
|
| Authors |
Rhys, Alexander D., Godinho, Susana A., Alexander D. Rhys, Susana A. Godinho |
| Editors |
Monica Gotta, Patrick Meraldi |
| Abstract |
The presence of supernumerary centrosomes is a hallmark of human tumours. Recent work in animal models suggests that extra centrosomes are not just bystanders in cancer but can accelerate tumourigenesis in the absence of the tumour suppressor p53. Centrosome amplification could indeed actively participate in tumour progression through the induction of chromosome instability, disruption of tissue architecture and promoting cell invasion. Paradoxically, however, centrosome amplification is rather poorly tolerated in normal cells and there are several hurdles cells need to overcome in order to efficiently proliferate in the presence of extra centrosomes. Here, we review the adaptation mechanisms that allow cells to efficiently divide in the presence of extra centrosomes and how these could be exploited to develop selective cancer therapies. |
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| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 31 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 23% |
| Researcher | 6 | 19% |
| Student > Bachelor | 5 | 16% |
| Student > Doctoral Student | 3 | 10% |
| Student > Master | 3 | 10% |
| Other | 4 | 13% |
| Unknown | 3 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 18 | 58% |
| Agricultural and Biological Sciences | 4 | 13% |
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| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
| Computer Science | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 3 | 10% |