Chapter title |
Insulin Resistance, Obesity and Lipotoxicity
|
---|---|
Chapter number | 12 |
Book title |
Obesity and Lipotoxicity
|
Published in |
Advances in experimental medicine and biology, June 2017
|
DOI | 10.1007/978-3-319-48382-5_12 |
Pubmed ID | |
Book ISBNs |
978-3-31-948380-1, 978-3-31-948382-5
|
Authors |
Dilek Yazıcı M.D., Havva Sezer M.D., Dilek Yazıcı, Havva Sezer, Yazıcı, Dilek, Sezer, Havva |
Editors |
Ayse Basak Engin, Atilla Engin |
Abstract |
Lipotoxicity , originally used to describe the destructive effects of excess fat accumulation on glucose metabolism, causes functional impairments in several metabolic pathways, both in adipose tissue and peripheral organs, like liver, heart, pancreas and muscle. Lipotoxicity has roles in insulin resistance and pancreatic beta cell dysfunction. Increased circulating levels of lipids and the metabolic alterations in fatty acid utilization and intracellular signaling, have been related to insulin resistance in muscle and liver. Different pathways, like novel protein kinase c pathways and the JNK-1 pathway are involved as the mechanisms of how lipotoxicity leads to insulin resistance in nonadipose tissue organs, such as liver and muscle. Mitochondrial dysfunction plays a role in the pathogenesis of insulin resistance. Endoplasmic reticulum stress, through mainly increased oxidative stress, also plays important role in the etiology of insulin resistance, especially seen in non-alcoholic fatty liver disease. Visceral adiposity and insulin resistance both increase the cardiometabolic risk and lipotoxicity seems to play a crucial role in the pathophysiology of these associations. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 366 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 53 | 14% |
Student > Master | 49 | 13% |
Student > Ph. D. Student | 43 | 12% |
Researcher | 28 | 8% |
Student > Doctoral Student | 18 | 5% |
Other | 37 | 10% |
Unknown | 138 | 38% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 65 | 18% |
Medicine and Dentistry | 60 | 16% |
Nursing and Health Professions | 26 | 7% |
Agricultural and Biological Sciences | 17 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 11 | 3% |
Other | 35 | 10% |
Unknown | 152 | 42% |