Chapter title |
Endothelial Dysfunction in Obesity
|
---|---|
Chapter number | 15 |
Book title |
Obesity and Lipotoxicity
|
Published in |
Advances in experimental medicine and biology, June 2017
|
DOI | 10.1007/978-3-319-48382-5_15 |
Pubmed ID | |
Book ISBNs |
978-3-31-948380-1, 978-3-31-948382-5
|
Authors |
Atilla Engin M.D., Ph.D., Atilla Engin, Engin, Atilla |
Editors |
Ayse Basak Engin, Atilla Engin |
Abstract |
Chronic inflammatory state in obesity causes dysregulation of the endocrine and paracrine actions of adipocyte-derived factors, which disrupt vascular homeostasis and contribute to endothelial vasodilator dysfunction and subsequent hypertension. While normal healthy perivascular adipose tissue (PVAT) ensures the dilation of blood vessels, obesity-associated PVAT leads to a change in profile of the released adipo-cytokines, resulting in a decreased vasorelaxing effect. Adipose tissue inflammation, nitric oxide (NO)-bioavailability, insulin resistance and oxidized low-density lipoprotein (oxLDL) are main participating factors in endothelial dysfunction of obesity. In this chapter, disruption of inter-endothelial junctions between endothelial cells, significant increase in the production of reactive oxygen species (ROS), inflammation mediators, which are originated from inflamed endothelial cells, the balance between NO synthesis and ROS , insulin signaling and NO production, and decrease in L-arginine/endogenous asymmetric dimethyl-L-arginine (ADMA) ratio are discussed in connection with endothelial dysfunction in obesity. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 144 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 17 | 12% |
Student > Doctoral Student | 17 | 12% |
Student > Ph. D. Student | 16 | 11% |
Student > Bachelor | 13 | 9% |
Researcher | 10 | 7% |
Other | 25 | 17% |
Unknown | 46 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 44 | 31% |
Biochemistry, Genetics and Molecular Biology | 14 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 6% |
Agricultural and Biological Sciences | 7 | 5% |
Sports and Recreations | 6 | 4% |
Other | 15 | 10% |
Unknown | 50 | 35% |