| Chapter title |
MicroRNA and Adipogenesis
|
|---|---|
| Chapter number | 21 |
| Book title |
Obesity and Lipotoxicity
|
| Published in |
Advances in experimental medicine and biology, June 2017
|
| DOI | 10.1007/978-3-319-48382-5_21 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-948380-1, 978-3-31-948382-5
|
| Authors |
Ayse Basak Engin Ph.D., Ph.D., Ayse Basak Engin, Engin, Ayse Basak |
| Editors |
Ayse Basak Engin, Atilla Engin |
| Abstract |
In obesity, the process of adipogenesis largely determines the number of adipocytes in body fat depots. Adipogenesis is regulated by several adipocyte-selective microRNAs (miRNAs) and transcription factors that modulate adipocyte proliferation and differentiation. However, some miRNAs block expression of master regulators of adipogenesis. Additionally, specific miRNAs have been implicated in adipocyte differentiation and mature adipocyte functions. While, each miRNA targets multiple mRNAs, which may coordinate or antagonize each other's functions, several miRNAs are dysregulated in other tissues during obesity-related comorbidities. In this respect, development of lipid droplets, macrophage accumulation, macrophage polarization, tumor necrosis factor receptor-associated factor 6 activity, lipolysis, lipotoxicity and insulin resistance are effectively controlled by miRNAs. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 43 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 8 | 19% |
| Student > Ph. D. Student | 8 | 19% |
| Researcher | 7 | 16% |
| Student > Master | 5 | 12% |
| Student > Postgraduate | 2 | 5% |
| Other | 2 | 5% |
| Unknown | 11 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 13 | 30% |
| Agricultural and Biological Sciences | 6 | 14% |
| Medicine and Dentistry | 5 | 12% |
| Nursing and Health Professions | 3 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Other | 0 | 0% |
| Unknown | 15 | 35% |