| Chapter title |
Using Ex Vivo Liver Organ Cultures to Measure Lymphocyte Trafficking
|
|---|---|
| Chapter number | 13 |
| Book title |
T-Cell Trafficking
|
| Published in |
Methods in molecular biology, March 2017
|
| DOI | 10.1007/978-1-4939-6931-9_13 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-6929-6, 978-1-4939-6931-9
|
| Authors |
Benjamin G. Wiggins B.Sc., M.Res., Zania Stamataki B.Sc. (Hons.), M.Sc., Ph.D., Patricia F. Lalor B.Sc., Ph.D., Benjamin G. Wiggins, Zania Stamataki, Patricia F. Lalor |
| Editors |
George Edward Rainger, Helen M. Mcgettrick |
| Abstract |
Lymphocyte recruitment to different organs, and even alternate anatomical regions within the same organ, is differentially regulated. Key combinations of adhesion molecules and chemokines govern compartmentalization, and these can change depending upon the nature and duration of tissue injury. We are interested in understanding lymphocyte recruitment to the liver during human disease, and thus need models of the liver inflammatory milieu that are as representative as possible. Here we describe the use of precision cut liver slices as models of disease. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 5 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 1 | 20% |
| Student > Bachelor | 1 | 20% |
| Lecturer > Senior Lecturer | 1 | 20% |
| Student > Master | 1 | 20% |
| Unknown | 1 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 2 | 40% |
| Biochemistry, Genetics and Molecular Biology | 1 | 20% |
| Chemistry | 1 | 20% |
| Engineering | 1 | 20% |