Chapter title |
Introduction to Lymphocyte Trafficking in Disease
|
---|---|
Chapter number | 12 |
Book title |
T-Cell Trafficking
|
Published in |
Methods in molecular biology, March 2017
|
DOI | 10.1007/978-1-4939-6931-9_12 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6929-6, 978-1-4939-6931-9
|
Authors |
Patricia F. Lalor B.Sc., Ph.D., Elizabeth A. Hepburn M.B.Ch.B., Patricia F. Lalor, Elizabeth A. Hepburn |
Editors |
George Edward Rainger, Helen M. Mcgettrick |
Abstract |
Lymphocytes are the key effector cells of the adaptive immune response but are also implicated in the development of chronic inflammatory diseases such as type 2 diabetes, cardiovascular disease, inflammatory bowel disease, and allergy. In order to understand the mechanisms responsible for the global increase in such debilitating conditions it is vital to appreciate the complexity of immune cell trafficking into tissue under normal and inflamed conditions. In this chapter we introduce the mechanisms of immune cell recruitment into tissue and highlight how these processes have been targeted by new therapeutic entities based on blocking integrin or chemokine function. |
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