Chapter title |
Vitamin A Transport and Cell Signaling by the Retinol-Binding Protein Receptor STRA6
|
---|---|
Chapter number | 3 |
Book title |
The Biochemistry of Retinoid Signaling II
|
Published in |
Sub cellular biochemistry, November 2016
|
DOI | 10.1007/978-94-024-0945-1_3 |
Pubmed ID | |
Book ISBNs |
978-9-40-240943-7, 978-9-40-240945-1
|
Authors |
Noa Noy |
Editors |
Mary Ann Asson-Batres, Cecile Rochette-Egly |
Abstract |
Vitamin A, retinol, circulates in blood bound to retinol binding protein (RBP). In some tissues, the retinol-RBP complex (holo-RBP) is recognized by a membrane receptor, termed STRA6, which mediates uptake of retinol into cells. Recent studies have revealed that, in addition to serving as a retinol transporter, STRA6 is a ligand-activated cell surface signaling receptor that, upon binding of holo-RBP activates JAK/STAT signaling, culminating in the induction of STAT target genes. It has further been shown that retinol transport and cell signaling by STRA6 are critically interdependent and that both are coupled to intracellular vitamin A metabolism. The molecular mechanism of action of STRA6 and its associated machinery is beginning to be revealed, but further work is needed to identify and characterize the complete range of genes and associated signaling cascades that are regulated by STRA6 in different tissues. An understanding of STRA6 is clinically relevant, as for example, it has been shown to be hyper- activated in obese animals, leading to insulin resistance. A potential role for STRA6 in other pathologies, including cancer, awaits further investigation. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 32 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 5 | 16% |
Student > Ph. D. Student | 5 | 16% |
Researcher | 4 | 13% |
Student > Doctoral Student | 2 | 6% |
Student > Bachelor | 2 | 6% |
Other | 5 | 16% |
Unknown | 9 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 7 | 22% |
Chemistry | 4 | 13% |
Neuroscience | 4 | 13% |
Chemical Engineering | 3 | 9% |
Medicine and Dentistry | 2 | 6% |
Other | 3 | 9% |
Unknown | 9 | 28% |