| Chapter title |
Genetic and Pharmacological Reversibility of Phenotypes in Mouse Models of Autism Spectrum Disorder
|
|---|---|
| Chapter number | 10 |
| Book title |
Translational Anatomy and Cell Biology of Autism Spectrum Disorder
|
| Published in |
Advances in anatomy embryology and cell biology, May 2017
|
| DOI | 10.1007/978-3-319-52498-6_10 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-952496-2, 978-3-31-952498-6
|
| Authors |
Jan C. Schroeder, Elena Deliu, Gaia Novarino, Michael J. Schmeisser, Schroeder, Jan C., Deliu, Elena, Novarino, Gaia, Schmeisser, Michael J. |
| Editors |
Michael J. Schmeisser, Tobias M. Boeckers |
| Abstract |
As autism spectrum disorder (ASD) is largely regarded as a neurodevelopmental condition, long-time consensus was that its hallmark features are irreversible. However, several studies from recent years using defined mouse models of ASD have provided clear evidence that in mice neurobiological and behavioural alterations can be ameliorated or even reversed by genetic restoration or pharmacological treatment either before or after symptom onset. Here, we review findings on genetic and pharmacological reversibility of phenotypes in mouse models of ASD. Our review should give a comprehensive overview on both aspects and encourage future studies to better understand the underlying molecular mechanisms that might be translatable from animals to humans. |
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