| Chapter title |
Cerebellar and Striatal Pathologies in Mouse Models of Autism Spectrum Disorder
|
|---|---|
| Chapter number | 6 |
| Book title |
Translational Anatomy and Cell Biology of Autism Spectrum Disorder
|
| Published in |
Advances in anatomy embryology and cell biology, May 2017
|
| DOI | 10.1007/978-3-319-52498-6_6 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-952496-2, 978-3-31-952498-6
|
| Authors |
Saša Peter, Chris I. De Zeeuw, Tobias M. Boeckers, Michael J. Schmeisser |
| Editors |
Michael J. Schmeisser, Tobias M. Boeckers |
| Abstract |
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with a strong genetic component. To date, several hundred different genetic mutations have been identified to play a role in its aetiology. The heterogeneity of genetic abnormalities combined with the different brain regions where aberrations are found makes the search for causative mechanisms a daunting task. Even within a limited number of brain regions, a myriad of different neural circuit dysfunctions may lead to ASD. Here, we review mouse models that incorporate mutations of ASD risk genes causing pathologies in the cerebellum and striatum and highlight the vulnerability of related circuit dysfunctions within these brain regions in ASD pathophysiology. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 30 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 20% |
| Student > Ph. D. Student | 5 | 17% |
| Student > Doctoral Student | 3 | 10% |
| Student > Bachelor | 3 | 10% |
| Student > Master | 2 | 7% |
| Other | 1 | 3% |
| Unknown | 10 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 12 | 40% |
| Agricultural and Biological Sciences | 3 | 10% |
| Psychology | 2 | 7% |
| Medicine and Dentistry | 2 | 7% |
| Environmental Science | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 10 | 33% |