Chapter title |
Vascular Reactivity of Isolated Aorta to Study the Angiotensin-(1-7) Actions
|
---|---|
Chapter number | 29 |
Book title |
Hypertension
|
Published in |
Methods in molecular biology, January 2017
|
DOI | 10.1007/978-1-4939-6625-7_29 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6623-3, 978-1-4939-6625-7
|
Authors |
Roberto Q. Lautner, Rodrigo A. Fraga-Silva, Anderson J. Ferreira, Robson A. S. Santos M.D., Ph.D., Robson A. S. Santos |
Editors |
Rhian M. Touyz, Ernesto L. Schiffrin |
Abstract |
Since the early 1950s, vascular reactivity using isolated vessel rings has been a useful and efficient model for physiological and pharmacological studies. This experimental model was utilized in the milestone study of Dr. Robert Furchgott to discover the endothelium-derived relaxation factor (EDRF) nitric oxide (NO), opening new avenues and scientific perspectives in the vascular pathophysiology. Moreover, the isolated vessel ring preparation had an important contribution to understand many vasoactive systems. Here, we described the isolated aorta technique and pitfalls about the use of angiotensin-(1-7) peptide in this preparation. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 5 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Professor | 1 | 20% |
Researcher | 1 | 20% |
Student > Postgraduate | 1 | 20% |
Unknown | 2 | 40% |
Readers by discipline | Count | As % |
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Pharmacology, Toxicology and Pharmaceutical Science | 1 | 20% |
Nursing and Health Professions | 1 | 20% |
Agricultural and Biological Sciences | 1 | 20% |
Medicine and Dentistry | 1 | 20% |
Unknown | 1 | 20% |