Chapter title |
Urine Metabolomics in Hypertension Research
|
---|---|
Chapter number | 5 |
Book title |
Hypertension
|
Published in |
Methods in molecular biology, January 2017
|
DOI | 10.1007/978-1-4939-6625-7_5 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6623-3, 978-1-4939-6625-7
|
Authors |
Sofia Tsiropoulou, Martin McBride, Sandosh Padmanabhan, Tsiropoulou, Sofia, McBride, Martin, Padmanabhan, Sandosh |
Editors |
Rhian M. Touyz, Ernesto L. Schiffrin |
Abstract |
Functional genomics requires an understanding of the complete network of changes within an organism by extensive measurements of moieties from mRNA, proteins, and metabolites. Metabolomics utilizes analytic chemistry tools to profile the complete spectrum of metabolites found in a tissue, cells, or biofluids using a wide range of tools from infrared spectroscopy, fluorescence spectroscopy, NMR spectroscopy, and mass spectrometry. In this protocol, we outline a procedure for performing metabolomic analysis of urine samples using liquid chromatography-mass spectrometry (LC-MS). We outline the advantages of using this approach and summarize some of the early promising studies in cardiovascular diseases using this approach. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 9 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 2 | 22% |
Student > Ph. D. Student | 1 | 11% |
Other | 1 | 11% |
Student > Bachelor | 1 | 11% |
Unknown | 4 | 44% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 3 | 33% |
Physics and Astronomy | 1 | 11% |
Biochemistry, Genetics and Molecular Biology | 1 | 11% |
Unknown | 4 | 44% |