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Mendeley readers
Chapter title |
Structural Characterization of Monomeric/Dimeric State of p59fyn SH2 Domain
|
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Chapter number | 14 |
Book title |
SH2 Domains
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Published in |
Methods in molecular biology, January 2017
|
DOI | 10.1007/978-1-4939-6762-9_14 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6760-5, 978-1-4939-6762-9
|
Authors |
Radu Huculeci, Fabien Kieken, Abel Garcia-Pino, Lieven Buts, Nico van Nuland, Tom Lenaerts |
Editors |
Kazuya Machida, Bernard A. Liu |
Abstract |
Src homology 2 (SH2) domains are key modulators in various signaling pathways allowing the recognition of phosphotyrosine sites of different proteins. Despite the fact that SH2 domains acquire their biological functions in a monomeric state, a multitude of reports have shown their tendency to dimerize. Here, we provide a technical description on how to isolate and characterize by gel filtration, circular dichroism (CD), and nuclear magnetic resonance (NMR) each conformational state of p59(fyn) SH2 domain. |
Mendeley readers
The data shown below were compiled from readership statistics for 2 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor > Associate Professor | 1 | 50% |
Other | 1 | 50% |
Readers by discipline | Count | As % |
---|---|---|
Computer Science | 1 | 50% |
Chemistry | 1 | 50% |