Chapter title |
Cryopreserved Adipose Tissue-Derived Stromal/Stem Cells: Potential for Applications in Clinic and Therapy
|
---|---|
Chapter number | 11 |
Book title |
Biobanking and Cryopreservation of Stem Cells
|
Published in |
Advances in experimental medicine and biology, November 2016
|
DOI | 10.1007/978-3-319-45457-3_11 |
Pubmed ID | |
Book ISBNs |
978-3-31-945455-9, 978-3-31-945457-3
|
Authors |
Fabiana Zanata, Shahensha Shaik, Ram V. Devireddy, Xiying Wu, Lydia Masako Ferreira, Jeffrey M. Gimble, Zanata, Fabiana, Shaik, Shahensha, Devireddy, Ram V., Wu, Xiying, Ferreira, Lydia Masako, Gimble, Jeffrey M. |
Editors |
Feridoun Karimi-Busheri, Michael Weinfeld |
Abstract |
Adipose-Derived Stromal/Stem Cells (ASC) have considerable potential for regenerative medicine due to their abilities to proliferate, differentiate into multiple cell lineages, high cell yield, relative ease of acquisition, and almost no ethical concerns since they are derived from adult tissue. Storage of ASC by cryopreservation has been well described that maintains high cell yield and viability, stable immunophenotype, and robust differentiation potential post-thaw. This ability is crucial for banking research and for clinical therapeutic purposes that avoid the morbidity related to repetitive liposuction tissue harvests. ASC secrete various biomolecules such as cytokines which are reported to have immunomodulatory properties and therapeutic potential to reverse symptoms of multiple degenerative diseases/disorders. Nevertheless, safety regarding the use of these cells clinically is still under investigation. This chapter focuses on the different aspects of cryopreserved ASC and the methods to evaluate their functionality for future clinical use. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 23 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 5 | 22% |
Lecturer | 3 | 13% |
Student > Doctoral Student | 2 | 9% |
Student > Bachelor | 2 | 9% |
Student > Ph. D. Student | 2 | 9% |
Other | 3 | 13% |
Unknown | 6 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 39% |
Biochemistry, Genetics and Molecular Biology | 3 | 13% |
Agricultural and Biological Sciences | 2 | 9% |
Neuroscience | 2 | 9% |
Immunology and Microbiology | 1 | 4% |
Other | 2 | 9% |
Unknown | 4 | 17% |