| Chapter title |
Anhydrobiosis: An Unsolved Problem with Applications in Human Welfare.
|
|---|---|
| Chapter number | 11 |
| Book title |
Membrane Hydration
|
| Published in |
Sub cellular biochemistry, January 2015
|
| DOI | 10.1007/978-3-319-19060-0_11 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-919059-4, 978-3-31-919060-0
|
| Authors |
John H. Crowe |
| Editors |
E. Anibal Disalvo |
| Abstract |
Anhydrobiosis (Life Without Water) has been known for millennia, but the underlying mechanisms have not been understood until recent decades, and we have achieved only a partial understanding. One of the chief sites of damage from dehydration is membranes, and we and others have provided evidence that this damage may be obviated by the production of certain sugars, particularly trehalose. The sugar stabilizes membranes by preventing fusion and fluidizing the dry bilayers. The mechanism by which this is accomplished has been controversial, and I review that controversy here. In the past decade evidence is accumulating for a role of stress proteins in addition to or as a substitute for trehalose. Genomic studies on anhydrobiotes are yielding rapid progress. Also in the past decade, numerous uses for trehalose in treating human diseases have been proposed, some of which are in clinical testing. I conclude that the mechanisms underlying anhydrobiosis are more complex than we thought 20 years ago, but progress is being made towards elucidating those mechanisms. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 25 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 6 | 24% |
| Researcher | 6 | 24% |
| Student > Ph. D. Student | 5 | 20% |
| Student > Doctoral Student | 1 | 4% |
| Professor | 1 | 4% |
| Other | 2 | 8% |
| Unknown | 4 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 40% |
| Agricultural and Biological Sciences | 5 | 20% |
| Chemistry | 3 | 12% |
| Engineering | 2 | 8% |
| Materials Science | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 3 | 12% |