Chapter title |
Genetic Regulation of Yersinia pestis.
|
---|---|
Chapter number | 8 |
Book title |
Yersinia pestis: Retrospective and Perspective
|
Published in |
Advances in experimental medicine and biology, January 2016
|
DOI | 10.1007/978-94-024-0890-4_8 |
Pubmed ID | |
Book ISBNs |
978-9-40-240888-1, 978-9-40-240890-4
|
Authors |
Yanping Han, Haihong Fang, Lei Liu, Dongsheng Zhou |
Editors |
Ruifu Yang, Andrey Anisimov |
Abstract |
Y. pestis exhibits dramatically different traits of pathogenicity and transmission, albeit their close genetic relationship with its ancestor-Y. pseudotuberculosis, a self-limiting gastroenteric pathogen. Y. pestis is evolved into a deadly pathogen and transmitted to mammals and/or human beings by infected flea biting or directly contacting with the infected animals. Various kinds of environmental changes are implicated into its complex life cycle and pathogenesis. Dynamic regulation of gene expression is critical for environmental adaptation or survival, primarily reflected by genetic regulation mediated by transcriptional factors and small regulatory RNAs at the transcriptional and posttranscriptional level, respectively. The effects of genetic regulation have been shown to profoundly influence Y. pestis physiology and pathogenesis such as stress resistance, biofilm formation, intracellular survival, and replication. In this chapter, we mainly summarize the progresses on popular methods of genetic regulation and on regulatory patterns and consequences of many key transcriptional and posttranscriptional regulators, with a particular emphasis on how genetic regulation influences the biofilm and virulence of Y. pestis. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 12 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 3 | 25% |
Student > Bachelor | 2 | 17% |
Librarian | 1 | 8% |
Researcher | 1 | 8% |
Unknown | 5 | 42% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 2 | 17% |
Biochemistry, Genetics and Molecular Biology | 1 | 8% |
Nursing and Health Professions | 1 | 8% |
Computer Science | 1 | 8% |
Medicine and Dentistry | 1 | 8% |
Other | 1 | 8% |
Unknown | 5 | 42% |