| Chapter title |
Genome and Evolution of Yersinia pestis.
|
|---|---|
| Chapter number | 6 |
| Book title |
Yersinia pestis: Retrospective and Perspective
|
| Published in |
Advances in experimental medicine and biology, January 2016
|
| DOI | 10.1007/978-94-024-0890-4_6 |
| Pubmed ID | |
| Book ISBNs |
978-9-40-240888-1, 978-9-40-240890-4
|
| Authors |
Yujun Cui, Yajun Song, Cui, Yujun, Song, Yajun |
| Editors |
Ruifu Yang, Andrey Anisimov |
| Abstract |
This chapter summarizes researches on genome and evolution features of Yersinia pestis, the young pathogen that evolved from Y. pseudotuberculosis at least 5000 years ago. Y. pestis is a highly clonal bacterial species with closed pan-genome. Comparative genomic analysis revealed that genome of Y. pestis experienced highly frequent rearrangement and genome decay events during the evolution. The genealogy of Y. pestis includes five major branches, and four of them seemed raised from a "big bang" node that is associated with the Black Death. Although whole genome-wide variation of Y. pestis reflected a neutral evolutionary process, the branch length in the genealogical tree revealed over dispersion, which was supposedly caused by varied historical molecular clock that is associated with demographical effect by alternate cycles of enzootic disease and epizootic disease in sylvatic plague foci. In recent years, palaeomicrobiology researches on victims of the Black Death, and Justinian's plague verified that two historical pandemics were indeed caused by Y. pestis, but the etiological lineages might be extinct today. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 5% |
| Unknown | 19 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 5 | 25% |
| Researcher | 5 | 25% |
| Student > Master | 3 | 15% |
| Student > Ph. D. Student | 1 | 5% |
| Professor | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 4 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 7 | 35% |
| Environmental Science | 2 | 10% |
| Nursing and Health Professions | 2 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
| Arts and Humanities | 1 | 5% |
| Other | 3 | 15% |
| Unknown | 4 | 20% |