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Type-1 Diabetes

Overview of attention for book
Cover of 'Type-1 Diabetes'

Table of Contents

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    Book Overview
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    Chapter 286 Methylation Analysis in Distinct Immune Cell Subsets in Type 1 Diabetes.
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    Chapter 287 Histology of Type 1 Diabetes Pancreas.
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    Chapter 288 Fluorescence In Situ Hybridization with Concomitant Immunofluorescence in Human Pancreas.
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    Chapter 289 Type 1 Diabetes: Current Perspectives.
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    Chapter 290 Laser Capture and Single Cell Genotyping from Frozen Tissue Sections.
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    Chapter 291 Pancreatic Beta Cell Survival and Signaling Pathways: Effects of Type 1 Diabetes-Associated Genetic Variants.
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    Chapter 292 Islet Autoantibody Analysis: Radioimmunoassays.
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    Chapter 293 Tracking Immunological Responses of Islet Antigen-Specific T Cells in the Nonobese Diabetic (NOD) Mouse Model of Type 1 Diabetes.
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    Chapter 294 Adoptive Transfer of Autoimmune Diabetes Using Immunodeficient Nonobese Diabetic (NOD) Mice.
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    Chapter 295 Identification of Islet Antigen-Specific CD8 T Cells Using MHCI-Peptide Tetramer Reagents in the Non Obese Diabetic (NOD) Mouse Model of Type 1 Diabetes.
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    Chapter 296 Islet Autoantibody Detection by Electrochemiluminescence (ECL) Assay.
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    Chapter 307 Type 1 Diabetes High-Risk HLA Class II Determination by Polymerase Chain Reaction Sequence-Specific Primers.
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    Chapter 330 Detection of C-Peptide in Urine as a Measure of Ongoing Beta Cell Function
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    Chapter 331 The Gut Microbiome in the NOD Mouse
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    Chapter 339 Molecular Methods and Protein Synthesis for Definition of Autoantibody Epitopes.
Attention for Chapter 307: Type 1 Diabetes High-Risk HLA Class II Determination by Polymerase Chain Reaction Sequence-Specific Primers.
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Chapter title
Type 1 Diabetes High-Risk HLA Class II Determination by Polymerase Chain Reaction Sequence-Specific Primers.
Chapter number 307
Book title
Type-1 Diabetes
Published in
Methods in molecular biology, December 2015
DOI 10.1007/7651_2015_307
Pubmed ID
Book ISBNs
978-1-4939-3641-0, 978-1-4939-3643-4
Authors

Rachel J. Aitken, Georgina L. Mortimer, Kathleen M. Gillespie

Editors

Kathleen M. Gillespie

Abstract

The only strategy to select individuals at increased risk for type 1 diabetes for primary prevention trials is through genetic risk assessment. While genome-wide association studies have identified more than 40 loci associated with type 1 diabetes, the single most important genetic determinants lie within the human leucocyte antigen gene family on chromosome 6.In this chapter we describe a protocol for a straightforward, cheap strategy to determine HLA class II mediated risk of type 1 diabetes. This method has proved robust for genotyping whole-genome-amplified DNA as well as DNA extracted directly from human tissues.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 1 13%
Researcher 1 13%
Other 1 13%
Student > Master 1 13%
Unknown 4 50%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 1 13%
Nursing and Health Professions 1 13%
Computer Science 1 13%
Medicine and Dentistry 1 13%
Unknown 4 50%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 November 2017.
All research outputs
#17,818,042
of 22,890,496 outputs
Outputs from Methods in molecular biology
#7,243
of 13,134 outputs
Outputs of similar age
#264,668
of 389,316 outputs
Outputs of similar age from Methods in molecular biology
#751
of 1,468 outputs
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