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Injury Models of the Central Nervous System

Overview of attention for book
Cover of 'Injury Models of the Central Nervous System'

Table of Contents

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    Book Overview
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    Chapter 1 The History and Evolution of Experimental Traumatic Brain Injury Models.
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    Chapter 2 Clinical Traumatic Brain Injury in the Preclinical Setting.
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    Chapter 3 Injury Models of the Central Nervous System
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    Chapter 4 Traumatic Brain Injury Models in Animals.
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    Chapter 5 Systematic Review of Traumatic Brain Injury Animal Models.
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    Chapter 6 Injury Models of the Central Nervous System
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    Chapter 7 Bridging the Gap of Standardized Animals Models for Blast Neurotrauma: Methodology for Appropriate Experimental Testing.
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    Chapter 8 Cellular Mechanisms and Behavioral Outcomes in Blast-Induced Neurotrauma: Comparing Experimental Setups.
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    Chapter 9 Application of Systems Biology to Neuroproteomics: The Path to Enhanced Theranostics in Traumatic Brain Injury.
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    Chapter 10 Role of Systems Biology in Brain Injury Biomarker Discovery: Neuroproteomics Application.
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    Chapter 11 The Controlled Cortical Impact Model of Experimental Brain Trauma: Overview, Research Applications, and Protocol.
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    Chapter 12 Weight Drop Models in Traumatic Brain Injury.
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    Chapter 13 Injury Models of the Central Nervous System
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    Chapter 14 Lateral (Parasagittal) Fluid Percussion Model of Traumatic Brain Injury.
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    Chapter 15 Injury Models of the Central Nervous System
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    Chapter 16 Experimental Models for Neurotrauma Research.
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    Chapter 17 A Porcine Model of Traumatic Brain Injury via Head Rotational Acceleration.
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    Chapter 18 Injury Models of the Central Nervous System
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    Chapter 19 Injury Models of the Central Nervous System
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    Chapter 20 Thromboembolic Model of Cerebral Ischemia and Reperfusion in Mice.
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    Chapter 21 Injury Models of the Central Nervous System
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    Chapter 22 Injury Models of the Central Nervous System
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    Chapter 23 Microdialysis as Clinical Evaluation of Therapeutic Hypothermia in Rat Subdural Hematoma Model.
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    Chapter 24 Repetitive Transcranial Magnetic Stimulation as a Novel Therapy in Animal Models of Traumatic Brain Injury.
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    Chapter 25 Experimental Models Combining TBI, Hemorrhagic Shock, and Hypoxemia.
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    Chapter 26 Injury Models of the Central Nervous System
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    Chapter 27 Animal Models of Posttraumatic Seizures and Epilepsy.
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    Chapter 28 Closed-Head TBI Model of Multiple Morbidity.
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    Chapter 29 Cognitive Evaluation Using Morris Water Maze in Neurotrauma.
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    Chapter 30 Assessment of Cognitive Function in the Water Maze Task: Maximizing Data Collection and Analysis in Animal Models of Brain Injury.
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    Chapter 31 Detecting Behavioral Deficits Post Traumatic Brain Injury in Rats.
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    Chapter 32 Advanced and High-Throughput Method for Mitochondrial Bioenergetics Evaluation in Neurotrauma.
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    Chapter 33 Determination of Vascular Reactivity of Middle Cerebral Arteries from Stroke and Spinal Cord Injury Animal Models Using Pressure Myography.
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    Chapter 34 Assessment of Basilar Artery Reactivity in Stroke and Subarachnoid Hemorrhage Using Wire Myograph.
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    Chapter 35 Injury Models of the Central Nervous System
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    Chapter 36 A Simplified Workflow for Protein Quantitation of Rat Brain Tissues Using Label-Free Proteomics and Spectral Counting.
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    Chapter 37 Phenotypic Screening of Small-Molecule Inhibitors: Implications for Therapeutic Discovery and Drug Target Development in Traumatic Brain Injury.
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    Chapter 38 Injury Models of the Central Nervous System
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    Chapter 39 Injury Models of the Central Nervous System
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    Chapter 40 Challenging the Paradigms of Experimental TBI Models: From Preclinical to Clinical Practice.
Attention for Chapter 31: Detecting Behavioral Deficits Post Traumatic Brain Injury in Rats.
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Chapter title
Detecting Behavioral Deficits Post Traumatic Brain Injury in Rats.
Chapter number 31
Book title
Injury Models of the Central Nervous System
Published in
Methods in molecular biology, January 2016
DOI 10.1007/978-1-4939-3816-2_31
Pubmed ID
27604739
Book ISBNs
978-1-4939-3814-8, 978-1-4939-3816-2
Authors

Hibah O. Awwad Ph.D., Awwad, Hibah O, Hibah O. Awwad

Editors

Firas H. Kobeissy, C. Edward Dixon, Ronald L. Hayes, Stefania Mondello

Abstract

Traumatic brain injury (TBI), ranging from mild to severe, almost always elicits an array of behavioral deficits in injured subjects. Some of these TBI-induced behavioral deficits include cognitive and vestibulomotor deficits as well as anxiety and other consequences. Rodent models of TBI have been (and still are) fundamental in establishing many of the pathophysiological mechanisms of TBI. Animal models are also utilized in screening and testing pharmacological effects of potential therapeutic agents for brain injury treatment. This chapter details validated protocols for each of these behavioral deficits post traumatic brain injury in Sprague-Dawley male rats. The elevated plus maze (EPM) protocol is described for assessing anxiety-like behavior; the Morris water maze protocol for assessing cognitive deficits in learning memory and spatial working memory and the rotarod test for assessing vestibulomotor deficits.

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X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 27%
Student > Doctoral Student 2 18%
Researcher 2 18%
Student > Master 1 9%
Student > Bachelor 1 9%
Other 0 0%
Unknown 2 18%
Readers by discipline Count As %
Neuroscience 4 36%
Psychology 4 36%
Computer Science 1 9%
Unknown 2 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 September 2016.
All research outputs
#14,861,191
of 22,888,307 outputs
Outputs from Methods in molecular biology
#4,702
of 13,132 outputs
Outputs of similar age
#219,031
of 393,716 outputs
Outputs of similar age from Methods in molecular biology
#469
of 1,471 outputs
Altmetric has tracked 22,888,307 research outputs across all sources so far. This one is in the 33rd percentile – i.e., 33% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,132 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 393,716 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1,471 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.

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