Chapter title |
Clinical Traumatic Brain Injury in the Preclinical Setting.
|
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Chapter number | 2 |
Book title |
Injury Models of the Central Nervous System
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-3816-2_2 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3814-8, 978-1-4939-3816-2
|
Authors |
Justin Berkner, Rebekah Mannix M.D., M.P.H., Jianhua Qiu M.D., Ph.D., Rebekah Mannix, Jianhua Qiu |
Editors |
Firas H. Kobeissy, C. Edward Dixon, Ronald L. Hayes, Stefania Mondello |
Abstract |
Traumatic brain injury (TBI) is the leading cause of death and disability for people under 45 years of age. Clinical TBI is often the result of disparate forces resulting in heterogeneous injuries. Preclinical modeling of TBI is a vital tool for studying the complex cascade of metabolic, cellular, and molecular post-TBI events collectively termed secondary injury. Preclinical models also provide an important platform for studying therapeutic interventions. However, modeling TBI in the preclinical setting is challenging, and most models replicate only certain aspects of clinical TBI. This chapter details the most widely used models of preclinical TBI, including the controlled cortical impact, fluid percussion, blast, and closed head models. Each of these models replicates particular critical aspects of clinical TBI. Prior to selecting a preclinical TBI model, it is important to address what aspect of human TBI is being sought to evaluate. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 18 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 3 | 17% |
Student > Bachelor | 2 | 11% |
Student > Doctoral Student | 2 | 11% |
Student > Postgraduate | 2 | 11% |
Student > Ph. D. Student | 2 | 11% |
Other | 4 | 22% |
Unknown | 3 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 4 | 22% |
Nursing and Health Professions | 2 | 11% |
Agricultural and Biological Sciences | 2 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
Environmental Science | 1 | 6% |
Other | 4 | 22% |
Unknown | 4 | 22% |