| Chapter title |
Repetitive Transcranial Magnetic Stimulation as a Novel Therapy in Animal Models of Traumatic Brain Injury.
|
|---|---|
| Chapter number | 24 |
| Book title |
Injury Models of the Central Nervous System
|
| Published in |
Methods in molecular biology, January 2016
|
| DOI | 10.1007/978-1-4939-3816-2_24 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-3814-8, 978-1-4939-3816-2
|
| Authors |
Thangavelu Soundara Rajan, Salvatore Cuzzocrea, Daniele Bruschetta, Angelo Quartarone M.D., Angelo Quartarone |
| Editors |
Firas H. Kobeissy, C. Edward Dixon, Ronald L. Hayes, Stefania Mondello |
| Abstract |
Traumatic brain injury (TBI) in humans causes a broad range of structural damage and functional deficits due to both primary and secondary injury mechanisms. Over the past three decades, animal models have been established to replicate the diverse changes of human TBI, to study the underlying pathophysiology and to develop new therapeutic strategies. However, drugs that were identified as neuroprotective in animal brain injury models were not successful in clinical trials phase II or phase III. Repetitive transcranial magnetic stimulation (rTMS) is a powerful noninvasive approach to excite cortical neurons in humans and animals, widely applied for therapeutic purpose in patients with brain diseases. In addition, recent animal studies showed rTMS as a strong neuroprotective tool. In this chapter, we discuss the rationale and mechanisms related to rTMS as well as therapeutic applications and putative molecular mechanisms. Furthermore, relevant biochemical studies and neuroprotective effect in animal models and possible application of rTMS as a novel treatment for rodent brain injury models are discussed. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 26 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 6 | 23% |
| Student > Bachelor | 4 | 15% |
| Student > Doctoral Student | 4 | 15% |
| Researcher | 3 | 12% |
| Other | 1 | 4% |
| Other | 4 | 15% |
| Unknown | 4 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 38% |
| Neuroscience | 4 | 15% |
| Psychology | 3 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
| Agricultural and Biological Sciences | 1 | 4% |
| Other | 3 | 12% |
| Unknown | 4 | 15% |