| Chapter title |
Injury Models of the Central Nervous System
|
|---|---|
| Chapter number | 21 |
| Book title |
Injury Models of the Central Nervous System
|
| Published in |
Methods in molecular biology, January 2016
|
| DOI | 10.1007/978-1-4939-3816-2_21 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-3814-8, 978-1-4939-3816-2
|
| Authors |
Ren, Changhong, Sy, Christopher, Gao, Jinhuan, Ding, Yuchuan, Ji, Xunming, Changhong Ren, Christopher Sy, Jinhuan Gao, Yuchuan Ding, Xunming Ji M.D., Ph.D., Xunming Ji |
| Editors |
Firas H. Kobeissy, C. Edward Dixon, Ronald L. Hayes, Stefania Mondello |
| Abstract |
Stroke is a major health issue worldwide-one with serious financial and public health implications. As a result, ongoing clinical research on novel and improved stroke therapies is not only pertinent but also paramount. Due to the complexity of a stroke-like event and its many sequelae, devising usable methods and experimental models are necessary to study and better understand the pathophysiological processes that ensue. As it stands, animal models that simulate stroke-like events have proven to be the most logical and effective options in regards to experimental studies. A number of animal stroke models exist and have been demonstrated in previous studies on ischemic as well as hemorrhagic stroke. Considering the efficiency and reproducibility of animal models, here, we introduce an ischemic stroke model induced by middle cerebral artery occlusion (MCAO) and an intracerebral hemorrhagic stroke model induced by collagenase injection. The models outlined here have been proven to demonstrate the clinical relevance desired for use in continued research on stroke pathophysiology and the study of future therapeutic options. |
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Demographic breakdown
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Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 13 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 3 | 23% |
| Student > Bachelor | 2 | 15% |
| Researcher | 2 | 15% |
| Student > Ph. D. Student | 1 | 8% |
| Student > Doctoral Student | 1 | 8% |
| Other | 1 | 8% |
| Unknown | 3 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 3 | 23% |
| Medicine and Dentistry | 2 | 15% |
| Biochemistry, Genetics and Molecular Biology | 1 | 8% |
| Veterinary Science and Veterinary Medicine | 1 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 8% |
| Other | 1 | 8% |
| Unknown | 4 | 31% |