Chapter title |
Injury Models of the Central Nervous System
|
---|---|
Chapter number | 18 |
Book title |
Injury Models of the Central Nervous System
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-3816-2_18 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3814-8, 978-1-4939-3816-2
|
Authors |
Semple, Bridgette D, Carlson, Jaclyn, Noble-Haeusslein, Linda J, Bridgette D. Semple, Jaclyn Carlson, Linda J. Noble-Haeusslein Ph.D., Firas H. Kobeissy, C. Edward Dixon, Ronald L. Hayes, Stefania Mondello, Linda J. Noble-Haeusslein, Semple, Bridgette D., Noble-Haeusslein, Linda J. |
Editors |
Firas H. Kobeissy, C. Edward Dixon, Ronald L. Hayes, Stefania Mondello |
Abstract |
Due to a high incidence of traumatic brain injury (TBI) in children and adolescents, age-specific studies are necessary to fully understand the long-term consequences of injuries to the immature brain. Preclinical and translational research can help elucidate the vulnerabilities of the developing brain to insult, and provide model systems to formulate and evaluate potential treatments aimed at minimizing the adverse effects of TBI. Several experimental TBI models have therefore been scaled down from adult rodents for use in juvenile animals. The following chapter discusses these adapted models for pediatric TBI, and the importance of age equivalence across species during model development and interpretation. Many neurodevelopmental processes are ongoing throughout childhood and adolescence, such that neuropathological mechanisms secondary to a brain insult, including oxidative stress, metabolic dysfunction and inflammation, may be influenced by the age at the time of insult. The long-term evaluation of clinically relevant functional outcomes is imperative to better understand the persistence and evolution of behavioral deficits over time after injury to the developing brain. Strategies to modify or protect against the chronic consequences of pediatric TBI, by supporting the trajectory of normal brain development, have the potential to improve quality of life for brain-injured children. |
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Members of the public | 1 | 100% |
Mendeley readers
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Unknown | 33 | 100% |
Demographic breakdown
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Researcher | 6 | 18% |
Student > Master | 6 | 18% |
Student > Ph. D. Student | 4 | 12% |
Other | 3 | 9% |
Student > Bachelor | 2 | 6% |
Other | 5 | 15% |
Unknown | 7 | 21% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 6 | 18% |
Neuroscience | 6 | 18% |
Psychology | 4 | 12% |
Nursing and Health Professions | 2 | 6% |
Chemical Engineering | 1 | 3% |
Other | 2 | 6% |
Unknown | 12 | 36% |