| Chapter title |
Measuring Vascular Permeability In Vivo.
|
|---|---|
| Chapter number | 6 |
| Book title |
The Tumor Microenvironment
|
| Published in |
Methods in molecular biology, January 2016
|
| DOI | 10.1007/978-1-4939-3801-8_6 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-3799-8, 978-1-4939-3801-8
|
| Authors |
Eelco F. J. Meijer, James W. Baish, Timothy P. Padera, Dai Fukumura |
| Editors |
Josie Ursini-Siegel, Nicole Beauchemin |
| Abstract |
Over the past decades, in vivo vascular permeability measurements have provided significant insight into vascular functions in physiological and pathophysiological conditions such as the response to pro- and anti-angiogenic signaling, abnormality of tumor vasculature and its normalization, and delivery and efficacy of therapeutic agents. Different approaches for vascular permeability measurements have been established. Here, we describe and discuss a conventional 2D imaging method to measure vascular permeability, which was originally documented by Gerlowski and Jain in 1986 (Microvasc Res 31:288-305, 1986) and further developed by Yuan et al. in the early 1990s (Microvasc Res 45:269-289, 1993; Cancer Res 54:352-3356, 1994), and our recently developed 3D imaging method, which advances the approach originally described by Brown et al. in 2001 (Nat Med 7:864-868, 2001). |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 30 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 23% |
| Student > Bachelor | 4 | 13% |
| Other | 3 | 10% |
| Researcher | 3 | 10% |
| Student > Master | 3 | 10% |
| Other | 6 | 20% |
| Unknown | 4 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 11 | 37% |
| Medicine and Dentistry | 5 | 17% |
| Agricultural and Biological Sciences | 3 | 10% |
| Biochemistry, Genetics and Molecular Biology | 2 | 7% |
| Immunology and Microbiology | 2 | 7% |
| Other | 3 | 10% |
| Unknown | 4 | 13% |