| Chapter title |
The Long and Short Non-coding RNAs in Cancer Biology
|
|---|---|
| Chapter number | 16 |
| Book title |
The Long and Short Non-coding RNAs in Cancer Biology
|
| Published in |
Advances in experimental medicine and biology, July 2016
|
| DOI | 10.1007/978-981-10-1498-7_16 |
| Pubmed ID | |
| Book ISBNs |
978-9-81-101496-3, 978-9-81-101498-7
|
| Authors |
Liu, Yang, Wang, Jun, Yang Liu, Jun Wang |
| Editors |
Erwei Song |
| Abstract |
Knowledge of multiple actions of short noncoding RNAs (ncRNAs) has truly allowed for viewing DNA, RNA, and protein in novel ways. The ncRNAs are an attractive new class of therapeutics, especially against undruggable targets for the treatment of cancer and other diseases. Despite the potential of ncRNAs in cancer therapy, many challenges remain, including rapid degradation and clearance, poor cellular uptake, off-target effects, and immunogenicity. Rational design, chemical modifications, and delivery carriers offer significant opportunities to overcome these challenges. In this chapter, the development of ncRNAs as cancer therapeutics from early stages to clinical trials and strategies for ncRNA-targeted delivery to cancer cells will be introduced. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| China | 1 | 8% |
| Unknown | 11 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 25% |
| Student > Bachelor | 2 | 17% |
| Researcher | 2 | 17% |
| Unknown | 5 | 42% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 3 | 25% |
| Medicine and Dentistry | 2 | 17% |
| Linguistics | 1 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 8% |
| Unknown | 5 | 42% |