| Chapter title |
The Long and Short Non-coding RNAs in Cancer Biology
|
|---|---|
| Chapter number | 4 |
| Book title |
The Long and Short Non-coding RNAs in Cancer Biology
|
| Published in |
Advances in experimental medicine and biology, July 2016
|
| DOI | 10.1007/978-981-10-1498-7_4 |
| Pubmed ID | |
| Book ISBNs |
978-9-81-101496-3, 978-9-81-101498-7
|
| Authors |
Suzuki, Hiromu, Maruyama, Reo, Yamamoto, Eiichiro, Niinuma, Takeshi, Kai, Masahiro, Hiromu Suzuki, Reo Maruyama, Eiichiro Yamamoto, Takeshi Niinuma, Masahiro Kai |
| Editors |
Erwei Song |
| Abstract |
Epigenetic alterations, including aberrant DNA methylation and histone modification, play key roles in the dysregulation of tumor-related genes, thereby affecting numerous cellular processes, including cell proliferation, cell adhesion, apoptosis, and metastasis. In recent years, studies have demonstrated that short and long noncoding RNAs (ncRNAs) are key players in the initiation and progression of cancer, and epigenetic mechanisms are deeply involved in their dysregulation. Indeed, the growing list of microRNA (miRNA) genes aberrantly methylated in cancer suggests that a large number of miRNAs act as tumor suppressors or oncogenes. In addition, emerging evidence suggests that dysregulation of long ncRNAs (lncRNAs) plays critical roles in tumorigenesis. And because ncRNAs are involved in regulating gene expression through interaction with epigenetic modifiers, their dysregulation appears causally related to epigenetic alterations in cancer. Dissection of the interrelationships between ncRNAs and epigenetic alterations has the potential to reveal novel approaches to the diagnosis and treatment of cancer. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| France | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Sweden | 1 | 6% |
| Germany | 1 | 6% |
| Unknown | 14 | 88% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 31% |
| Student > Bachelor | 3 | 19% |
| Unspecified | 1 | 6% |
| Researcher | 1 | 6% |
| Student > Doctoral Student | 1 | 6% |
| Other | 0 | 0% |
| Unknown | 5 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 2 | 13% |
| Medicine and Dentistry | 2 | 13% |
| Agricultural and Biological Sciences | 1 | 6% |
| Unspecified | 1 | 6% |
| Immunology and Microbiology | 1 | 6% |
| Other | 1 | 6% |
| Unknown | 8 | 50% |