Chapter title |
Serial Femtosecond Crystallography of Membrane Proteins.
|
---|---|
Chapter number | 11 |
Book title |
The Next Generation in Membrane Protein Structure Determination
|
Published in |
Advances in experimental medicine and biology, August 2016
|
DOI | 10.1007/978-3-319-35072-1_11 |
Pubmed ID | |
Book ISBNs |
978-3-31-935070-7, 978-3-31-935072-1
|
Authors |
Lan Zhu, Uwe Weierstall, Vadim Cherezov, Wei Liu |
Editors |
Isabel Moraes |
Abstract |
Membrane proteins, including G protein-coupled receptors (GPCRs), constitute the most important drug targets. The increasing number of targets requires new structural information, which has proven tremendously challenging due to the difficulties in growing diffraction-quality crystals. Recent developments of serial femtosecond crystallography at X-ray free electron lasers combined with the use of membrane-mimetic gel-like matrix of lipidic cubic phase (LCP-SFX) for crystal growth and delivery hold significant promise to accelerate structural studies of membrane proteins. This chapter describes the development and current status of the LCP-SFX technology and elaborates its future role in structural biology of membrane proteins. |
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Members of the public | 2 | 100% |
Mendeley readers
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Unknown | 17 | 100% |
Demographic breakdown
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Student > Ph. D. Student | 3 | 18% |
Researcher | 3 | 18% |
Student > Bachelor | 2 | 12% |
Student > Master | 2 | 12% |
Professor | 1 | 6% |
Other | 1 | 6% |
Unknown | 5 | 29% |
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Unspecified | 1 | 6% |
Agricultural and Biological Sciences | 1 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
Other | 2 | 12% |
Unknown | 5 | 29% |