Chapter title |
Beyond Membrane Protein Structure: Drug Discovery, Dynamics and Difficulties.
|
---|---|
Chapter number | 12 |
Book title |
The Next Generation in Membrane Protein Structure Determination
|
Published in |
Advances in experimental medicine and biology, August 2016
|
DOI | 10.1007/978-3-319-35072-1_12 |
Pubmed ID | |
Book ISBNs |
978-3-31-935070-7, 978-3-31-935072-1
|
Authors |
Philip C. Biggin, Matteo Aldeghi, Michael J. Bodkin, Alexander Heifetz, Biggin, Philip C, Aldeghi, Matteo, Bodkin, Michael J, Heifetz, Alexander |
Editors |
Isabel Moraes |
Abstract |
Most of the previous content of this book has focused on obtaining the structures of membrane proteins. In this chapter we explore how those structures can be further used in two key ways. The first is their use in structure based drug design (SBDD) and the second is how they can be used to extend our understanding of their functional activity via the use of molecular dynamics. Both aspects now heavily rely on computations. This area is vast, and alas, too large to consider in depth in a single book chapter. Thus where appropriate we have referred the reader to recent reviews for deeper assessment of the field. We discuss progress via the use of examples from two main drug target areas; G-protein coupled receptors (GPCRs) and ion channels. We end with a discussion of some of the main challenges in the area. |
X Demographics
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United Kingdom | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 19 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 8 | 42% |
Researcher | 6 | 32% |
Student > Bachelor | 1 | 5% |
Unspecified | 1 | 5% |
Professor | 1 | 5% |
Other | 1 | 5% |
Unknown | 1 | 5% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 7 | 37% |
Chemistry | 4 | 21% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 11% |
Chemical Engineering | 1 | 5% |
Unspecified | 1 | 5% |
Other | 2 | 11% |
Unknown | 2 | 11% |