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The Next Generation in Membrane Protein Structure Determination

Overview of attention for book
Attention for Chapter 11: Serial Femtosecond Crystallography of Membrane Proteins.
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Chapter title
Serial Femtosecond Crystallography of Membrane Proteins.
Chapter number 11
Book title
The Next Generation in Membrane Protein Structure Determination
Published in
Advances in experimental medicine and biology, August 2016
DOI 10.1007/978-3-319-35072-1_11
Pubmed ID
Book ISBNs
978-3-31-935070-7, 978-3-31-935072-1
Authors

Lan Zhu, Uwe Weierstall, Vadim Cherezov, Wei Liu

Editors

Isabel Moraes

Abstract

Membrane proteins, including G protein-coupled receptors (GPCRs), constitute the most important drug targets. The increasing number of targets requires new structural information, which has proven tremendously challenging due to the difficulties in growing diffraction-quality crystals. Recent developments of serial femtosecond crystallography at X-ray free electron lasers combined with the use of membrane-mimetic gel-like matrix of lipidic cubic phase (LCP-SFX) for crystal growth and delivery hold significant promise to accelerate structural studies of membrane proteins. This chapter describes the development and current status of the LCP-SFX technology and elaborates its future role in structural biology of membrane proteins.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 18%
Researcher 3 18%
Student > Bachelor 2 12%
Student > Master 2 12%
Professor 1 6%
Other 1 6%
Unknown 5 29%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 24%
Physics and Astronomy 3 18%
Unspecified 1 6%
Agricultural and Biological Sciences 1 6%
Pharmacology, Toxicology and Pharmaceutical Science 1 6%
Other 2 12%
Unknown 5 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 March 2017.
All research outputs
#17,964,768
of 23,072,295 outputs
Outputs from Advances in experimental medicine and biology
#3,122
of 4,977 outputs
Outputs of similar age
#247,954
of 342,228 outputs
Outputs of similar age from Advances in experimental medicine and biology
#46
of 78 outputs
Altmetric has tracked 23,072,295 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,977 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 342,228 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.