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Metabolism in Cancer

Overview of attention for book
Attention for Chapter 4: Metabolism in Cancer
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Mentioned by

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3 tweeters

Citations

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6 Dimensions

Readers on

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18 Mendeley
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Chapter title
Metabolism in Cancer
Chapter number 4
Book title
Metabolism in Cancer
Published in
Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer, August 2016
DOI 10.1007/978-3-319-42118-6_4
Pubmed ID
Book ISBNs
978-3-31-942116-2, 978-3-31-942118-6
Authors

Hsieh, Annie L, Dang, Chi V, Annie L. Hsieh, Chi V. Dang, Hsieh, Annie L., Dang, Chi V.

Editors

Thorsten Cramer, Clemens A. Schmitt

Abstract

The MYC oncogene plays a pivotal role in the development and progression of human cancers. It encodes a transcription factor that has broad reaching effects on many cellular functions, most importantly in driving cell growth through regulation of genes involved in ribosome biogenesis, metabolism, and cell cycle. Upon binding DNA with its partner MAX, MYC recruits factors that release paused RNA polymerases to drive transcription and amplify gene expression. At physiologic levels of MYC, occupancy of high-affinity DNA-binding sites drives 'house-keeping' metabolic genes and those involved in ribosome and mitochondrial biogenesis for biomass accumulation. At high oncogenic levels of MYC, invasion of low-affinity sites and enhancer sequences alter the transcriptome and cause metabolic imbalances, which activates stress response and checkpoints such as p53. Loss of checkpoints unleashes MYC's full oncogenic potential to couple metabolism with neoplastic cell growth and division. Cells that overexpress MYC, however, are vulnerable to metabolic perturbations that provide potential new avenues for cancer therapy.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 6%
Unknown 17 94%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 17%
Student > Master 3 17%
Student > Ph. D. Student 3 17%
Student > Doctoral Student 2 11%
Professor > Associate Professor 2 11%
Other 1 6%
Unknown 4 22%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 22%
Medicine and Dentistry 4 22%
Agricultural and Biological Sciences 3 17%
Chemistry 2 11%
Materials Science 1 6%
Other 0 0%
Unknown 4 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 August 2016.
All research outputs
#13,462,097
of 22,013,594 outputs
Outputs from Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer
#86
of 170 outputs
Outputs of similar age
#150,003
of 287,435 outputs
Outputs of similar age from Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer
#1
of 1 outputs
Altmetric has tracked 22,013,594 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 170 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.1. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 287,435 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them