Chapter title |
Outcome, Pressure Reactivity and Optimal Cerebral Perfusion Pressure Calculation in Traumatic Brain Injury: A Comparison of Two Variants.
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Chapter number | 44 |
Book title |
Intracranial Pressure and Brain Monitoring XV
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Published in |
Acta neurochirurgica Supplement, January 2016
|
DOI | 10.1007/978-3-319-22533-3_44 |
Pubmed ID | |
Book ISBNs |
978-3-31-922532-6, 978-3-31-922533-3
|
Authors |
Lang, Erhard W, Kasprowicz, Magdalena, Smielewski, Peter, Santos, Edgar, Pickard, John, Czosnyka, Marek, Erhard W. Lang MD, PhD, Magdalena Kasprowicz PhD, Peter Smielewski PhD, Edgar Santos MD, John Pickard FRCS (SN), FMedSci, Marek Czosnyka PhD, Lang, Erhard W., Erhard W. Lang, Magdalena Kasprowicz, Peter Smielewski, Edgar Santos, John Pickard, Marek Czosnyka |
Editors |
Beng-Ti Ang |
Abstract |
This study investigates the outcome prediction and calculation of optimal cerebral perfusion pressure (CPPopt) in 307 patients after severe traumatic brain injury (TBI) based on cerebrovascular reactivity calculation of a moving correlation correlation coefficient, named PRx, between mean arterial pressure (ABP) and intracranial pressure (ICP). The correlation coefficient was calculated from simultaneously recorded data using different frequencies. PRx was calculated from oscillations between 0.008 and 0.05Hz and the longPRx (L-PRx) was calculated from oscillations between 0.0008 and 0.016 Hz. PRx was a significant mortality predictor, whereas L-PRx was not. CPPopt for pooled data was higher for L-PRx than for PRx, with no statistical difference. Mortality was associated with mean CPP below CPPopt. Severe disability was associated with CPP above CPPopt (PRx). These relationships were not statistically significant for CPPopt (L-PRx). We conclude that PRx and L-PRx cannot be used interchangeably. |
Mendeley readers
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Demographic breakdown
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Student > Ph. D. Student | 3 | 8% |
Other | 5 | 14% |
Unknown | 11 | 30% |
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Other | 3 | 8% |
Unknown | 10 | 27% |